Effects of customized CAD/CAM abutments on cytokine levels in peri-implant crevicular fluid during early implant healing: a pilot study.
Bone implant interface
Cytokines
Dental implant-abutment design
Osseointegration
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
13
07
2022
accepted:
04
12
2022
medline:
15
6
2023
pubmed:
25
12
2022
entrez:
24
12
2022
Statut:
ppublish
Résumé
This study aimed to assess levels of biomarkers associated with inflammation and tissue destruction in peri-implant crevicular fluid (PICF) of implants provided with customized or standard healing abutments during early implant healing. Thirty implants were placed in 22 patients with partial posterior edentulism. Subsequently, test group implants (n=15) received one-piece titanium abutments that were fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM). Control group implants (n=15) were provided with standard abutments. PICF collection and standardized periapical radiographs were carried out at suture removal one week later, following crown delivery after 3 months and at 6 months. Expression of C-reactive protein (CRP), interferon-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12A, IL-17A, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase (MMP)-13, osteopontin, osteoactivin, Receptor Activator of NF-κB (RANK), and TGF-β were analyzed using a multiplex ELISA kit. Both groups showed a significant decrease in protein expression of CRP, IL-1β, IL-6, IL-8, MIP-1α, osteopontin, osteoactivin, and TGF-β, while MMP-13 levels increased during the observation period. A rise in OPG and RANK levels was detected among customized abutments. Expression of CRP was higher, whereas IL-1β, IL-1α, and MIP-1α were decreased in control compared to test group implants after 6 months. Marginal bone loss did not depend on abutment modality. Both abutment types showed distinctive temporal expression of inflammatory biomarkers during 6 months following implant placement. ISRCTN98477184, registration date 18/05/2022 CLINICAL RELEVANCE: Customized healing abutments exert similar effects on inflammation during early implant healing compared to standard healing abutments.
Identifiants
pubmed: 36565371
doi: 10.1007/s00784-022-04826-x
pii: 10.1007/s00784-022-04826-x
pmc: PMC10264526
doi:
Substances chimiques
Dental Implants
0
Chemokine CCL3
0
Osteopontin
106441-73-0
Interleukin-6
0
Interleukin-8
0
Tumor Necrosis Factor-alpha
0
Interleukin-1alpha
0
Transforming Growth Factor beta
0
Titanium
D1JT611TNE
Types de publication
Journal Article
Langues
eng
Pagination
2621-2628Informations de copyright
© 2022. The Author(s).
Références
Sculean A, Gruber R, Bosshardt DD (2014) “Soft tissue wound healing around teeth and dental implants,” (in eng). J Clin Periodontol 41(Suppl 15):S6-22. https://doi.org/10.1111/jcpe.12206
doi: 10.1111/jcpe.12206
pubmed: 24641001
Berglundh T, Lindhe J (1996) Dimension of the periimplant mucosa Biological width revisited. J Clin Periodontol 23(10):971–3. https://doi.org/10.1111/j.1600-051x.1996.tb00520.x . ((in eng))
doi: 10.1111/j.1600-051x.1996.tb00520.x
pubmed: 8915028
Cochran DL, Hermann JS, Schenk RK, Higginbottom FL, Buser D (1997) “Biologic width around titanium implants A histometric analysis of the implanto-gingival junction around unloaded and loaded nonsubmerged implants in the canine mandible,” (in eng). J Periodontol 68(2):186–98. https://doi.org/10.1902/jop.1997.68.2.186
doi: 10.1902/jop.1997.68.2.186
pubmed: 9058338
Koutouzis T, Gholami F, Reynolds J, Lundgren T, Kotsakis GA (2017) “Abutment disconnection/reconnection affects peri-implant marginal bone levels: a meta-analysis,” (in eng). Int J Oral Maxillofac Implants 32(3):575–581. https://doi.org/10.11607/jomi.5367
doi: 10.11607/jomi.5367
pubmed: 28334059
Iglhaut G, Becker K, Golubovic V, Schliephake H, Mihatovic I (2013) “The impact of dis-/reconnection of laser microgrooved and machined implant abutments on soft- and hard-tissue healing,” (in eng). Clin Oral Implants Res 24(4):391–7. https://doi.org/10.1111/clr.12040
doi: 10.1111/clr.12040
pubmed: 23009248
Becker K, Mihatovic I, Golubovic V, Schwarz F (2012) “Impact of abutment material and dis-/re-connection on soft and hard tissue changes at implants with platform-switching,” (in eng). J Clin Periodontol 39(8):774–80. https://doi.org/10.1111/j.1600-051X.2012.01911.x
doi: 10.1111/j.1600-051X.2012.01911.x
pubmed: 22676071
Abrahamsson I, Berglundh T, Lindhe J (1997) “The mucosal barrier following abutment dis/reconnection An experimental study in dogs,” (in eng). J Clin Periodontol 24(8):568–72. https://doi.org/10.1111/j.1600-051x.1997.tb00230.x
doi: 10.1111/j.1600-051x.1997.tb00230.x
pubmed: 9266344
Molina A, Sanz-Sánchez I, Martín C, Blanco J, Sanz M (2017) “The effect of one-time abutment placement on interproximal bone levels and peri-implant soft tissues: a prospective randomized clinical trial,” (in eng). Clin Oral Implants Res 28(4):443–452. https://doi.org/10.1111/clr.12818
doi: 10.1111/clr.12818
pubmed: 27016157
Perrotti V, Zhang D, Liang A, Wong J, Quaranta A (2019) “The effect of one-abutment at one-time on marginal bone loss around implants placed in healed bone: a systematic review of human studies,” (in eng). Implant Dent 28(6):603–612. https://doi.org/10.1097/ID.0000000000000931
doi: 10.1097/ID.0000000000000931
pubmed: 31373902
Faot F, Nascimento GG, Bielemann AM, Campão TD, Leite FR, Quirynen M (2015) “Can peri-implant crevicular fluid assist in the diagnosis of peri-implantitis? A systematic review and meta-analysis,” (in eng). J Periodontol 86(5):631–45. https://doi.org/10.1902/jop.2015.140603
doi: 10.1902/jop.2015.140603
pubmed: 25675962
Kuppusamy M, Watanabe H, Kasugai S, Kuroda S (2015) “Effects of abutment removal and reconnection on inflammatory cytokine production around dental implants,” (in eng). Implant Dent 24(6):730–4. https://doi.org/10.1097/ID.0000000000000330
doi: 10.1097/ID.0000000000000330
pubmed: 26428012
Atieh MA, Tawse-Smith A, Alsabeeha NHM, Ma S, Duncan WJ (2017) The one abutment-one time protocol: a systematic review and meta-analysis. J Periodontol 88(11):1173–1185. https://doi.org/10.1902/jop.2017.170238 . (in eng)
doi: 10.1902/jop.2017.170238
pubmed: 28625076
Long L, Alqarni H, Masri R (2017) “Influence of implant abutment fabrication method on clinical outcomes: a systematic review,” (in eng). Eur J Oral Implantol 10(1):67–77
pubmed: 28944369
Laskin DM, Dent CD, Morris HF, Ochi S, Olson JW (2000) “The influence of preoperative antibiotics on success of endosseous implants at 36 months,” (in eng). Ann Periodontol 5(1):166–74. https://doi.org/10.1902/annals.2000.5.1.166
doi: 10.1902/annals.2000.5.1.166
pubmed: 11885177
Giannobile WV, Lynch SE, Denmark RG, Paquette DW, Fiorellini JP, Williams RC (1995) “Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis A pilot study in beagle dogs,” (in eng). J Clin Periodontol 22(12):903–10. https://doi.org/10.1111/j.1600-051x.1995.tb01793.x
doi: 10.1111/j.1600-051x.1995.tb01793.x
pubmed: 8613557
Calvo-Guirado JL et al (2018) “Peri-implant bone loss clinical and radiographic evaluation around rough neck and microthread implants: a 5-year study,” (in eng). Clin Oral Implants Res 29(6):635–643. https://doi.org/10.1111/clr.12775
doi: 10.1111/clr.12775
pubmed: 26744262
Di Paolo NC, Shayakhmetov DM (2016) “Interleukin 1α and the inflammatory process,” (in eng). Nat Immunol 17(8):906. https://doi.org/10.1038/ni.3503
doi: 10.1038/ni.3503
pubmed: 27434011
pmcid: 5152572
Wang IC, Sugai JV, Majzoub J, Johnston J, Giannobile WV, Wang HL (2021) “Pro-inflammatory profiles in cardiovascular disease patients with peri-implantitis,” (in eng). J Periodontol. https://doi.org/10.1002/JPER.21-0419
doi: 10.1002/JPER.21-0419
pubmed: 34709660
pmcid: 8941487
Hentenaar DFM et al (2021) “Biomarker levels in peri-implant crevicular fluid of healthy implants, untreated and non-surgically treated implants with peri-implantitis,” (in eng). J Clin Periodontol 48(4):590–601. https://doi.org/10.1111/jcpe.13423
doi: 10.1111/jcpe.13423
pubmed: 33454996
Petković AB et al (2010) “Proinflammatory cytokines (IL-1beta and TNF-alpha) and chemokines (IL-8 and MIP-1alpha) as markers of peri-implant tissue condition,” (in eng). Int J Oral Maxillofac Surg 39(5):478–85. https://doi.org/10.1016/j.ijom.2010.01.014
doi: 10.1016/j.ijom.2010.01.014
pubmed: 20207110
Bhavsar I, Miller CS, Ebersole JL, Dawson DR, Thompson KL, Al-Sabbagh M (2019) “Biological response to peri-implantitis treatment,” (in eng). J Periodontal Res 54(6):720–728. https://doi.org/10.1111/jre.12681
doi: 10.1111/jre.12681
pubmed: 31321776
Lund SA, Giachelli CM, Scatena M (2009) “The role of osteopontin in inflammatory processes,” (in eng). J Cell Commun Signal 3(3–4):311–22. https://doi.org/10.1007/s12079-009-0068-0
doi: 10.1007/s12079-009-0068-0
pubmed: 19798593
pmcid: 2778587
Abdelmagid SM et al (2008) “Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function,” (in eng). Exp Cell Res 314(13):2334–51. https://doi.org/10.1016/j.yexcr.2008.02.006
doi: 10.1016/j.yexcr.2008.02.006
pubmed: 18555216
Saade M, Araujo de Souza G, Scavone C, Kinoshita PF (2021) “The role of GPNMB in inflammation,” (in eng). Front Immunol 12:674739. https://doi.org/10.3389/fimmu.2021.674739
doi: 10.3389/fimmu.2021.674739
pubmed: 34054862
pmcid: 8149902
Toriseva M et al (2012) “MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability,” (in eng). PLoS One 7(8):e42596. https://doi.org/10.1371/journal.pone.0042596
doi: 10.1371/journal.pone.0042596
pubmed: 22880047
pmcid: 3413640
Rakic M, Lekovic V, Nikolic-Jakoba N, Vojvodic D, Petkovic-Curcin A, Sanz M (2013) “Bone loss biomarkers associated with peri-implantitis A cross-sectional study,” (in eng). Clin Oral Implants Res 24(10):1110–6. https://doi.org/10.1111/j.1600-0501.2012.02518.x
doi: 10.1111/j.1600-0501.2012.02518.x
pubmed: 22708989
Albrektsson T, Chrcanovic B, Östman PO, Sennerby L (2000) 2017 “Initial and long-term crestal bone responses to modern dental implants,” (in eng). Periodontol 73(1):41–50. https://doi.org/10.1111/prd.12176
doi: 10.1111/prd.12176
Moreira F, Rocha S, Caramelo F, Tondela JP (2021) “One-abutment one-time effect on peri-implant marginal bone: a prospective, controlled, randomized, double-blind study,” (in eng). Materials (Basel) 14:15. https://doi.org/10.3390/ma14154179
doi: 10.3390/ma14154179
Andrukhov O et al (2020) “Effect of implant surface material and roughness to the susceptibility of primary gingival fibroblasts to inflammatory stimuli,” (in eng). Dent Mater 36(6):e194–e205. https://doi.org/10.1016/j.dental.2020.04.003
doi: 10.1016/j.dental.2020.04.003
pubmed: 32360041
Serichetapongse P, Madarasmi R, Vacharaksa A (2022) “Host responses in peri-implant tissue in comparison to periodontal tissue: a retrospective study,” (in eng). Oral Health Prev Dent 20(1):41–50. https://doi.org/10.3290/j.ohpd.b2585655
doi: 10.3290/j.ohpd.b2585655
pubmed: 35049254