Early prediction and longitudinal modeling of preeclampsia from multiomics.
biomarkers
machine learning
multiomics
predictive modeling
preeclampsia
Journal
Patterns (New York, N.Y.)
ISSN: 2666-3899
Titre abrégé: Patterns (N Y)
Pays: United States
ID NLM: 101767765
Informations de publication
Date de publication:
09 Dec 2022
09 Dec 2022
Historique:
received:
27
09
2022
revised:
28
09
2022
accepted:
11
11
2022
entrez:
26
12
2022
pubmed:
27
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear. We developed machine-learning models for early prediction of preeclampsia (first 16 weeks of pregnancy) and over gestation by analyzing six omics datasets from a longitudinal cohort of pregnant women. For early pregnancy, a prediction model using nine urine metabolites had the highest accuracy and was validated on an independent cohort (area under the receiver-operating characteristic curve [AUC] = 0.88, 95% confidence interval [CI] [0.76, 0.99] cross-validated; AUC = 0.83, 95% CI [0.62,1] validated). Univariate analysis demonstrated statistical significance of identified metabolites. An integrated multiomics model further improved accuracy (AUC = 0.94). Several biological pathways were identified including tryptophan, caffeine, and arachidonic acid metabolisms. Integration with immune cytometry data suggested novel associations between immune and proteomic dynamics. While further validation in a larger population is necessary, these encouraging results can serve as a basis for a simple, early diagnostic test for preeclampsia.
Identifiants
pubmed: 36569558
doi: 10.1016/j.patter.2022.100655
pii: S2666-3899(22)00295-1
pmc: PMC9768681
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100655Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM138353
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
S.R.Q. is a founder, consultant, and shareholder of Mirvie. M.N.M. is a shareholder of Mirvie. D.A.R. is a shareholder of Blue Willow Biologics, Cantata Bio, Evelo Biosciences, Karius, Proderm IQ, and Second Genome. D.A.R. is an advisor to Cantata Bio and Visby Medical. K.G.S. is paid advisor of Mission Biocapital and Infinant Health; equity holder and paid advisor of Avexegen; and equity holder of mProbe. M.P.S. is a co-founder and scientific advisor of Personalis, SensOmics, Qbio, January AI, Fodsel, Filtricine, Protos, RTHM, Iollo, Marble Therapeutics, and Mirvie, and a scientific advisor of Genapsys, Jupiter, Neuvivo, Swaza, and Mitrix.
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