Tei Index Complements Conventional Echocardiographic Parameters in Diagnostic Workup of Suspected Takotsubo Syndrome.
Acute coronary syndrome
Myocardial performance index
Takotsubo syndrome
Tei index
Journal
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
ISSN: 1423-0151
Titre abrégé: Med Princ Pract
Pays: Switzerland
ID NLM: 8901334
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
10
2022
accepted:
06
12
2022
medline:
5
6
2023
pubmed:
27
12
2022
entrez:
26
12
2022
Statut:
ppublish
Résumé
Tei index (TI) is a combined myocardial performance index for overall cardiac function, the sensitivity of which seems to be better than that of systolic and diastolic parameters alone. Evidence for TI in the context of Takotsubo syndrome (TTS) is currently limited, which is why we chose to investigate this parameter in affected patients. Patients with TTS (n = 51), acute coronary syndrome (ACS; n = 29), and controls (n = 58) were retrospectively investigated. Laboratory and echocardiographic parameters including TI were analyzed for their ability to discriminate TTS in the total study cohort. TI was the highest, and thus most pathological, in patients with TTS (median 0.516 vs. ACS: 0.355 vs. control: 0.313, p < 0.0001) and showed the best discriminatory ability for TTS (AUC: 0.836, p < 0.0001). A cut-off for diagnosis of TTS was calculated at ≥0.418 (specificity: 83.5% and sensitivity: 74.0%) by means of the Youden index. The discriminatory ability of TI was better than that of other echocardiographic parameters such as LV systolic function. Due to the simple, fast, and inexpensive way of calculating TI, diagnostic workup with conventional parameters could be complemented by TI in patients with suspected TTS.
Sections du résumé
BACKGROUND
Tei index (TI) is a combined myocardial performance index for overall cardiac function, the sensitivity of which seems to be better than that of systolic and diastolic parameters alone. Evidence for TI in the context of Takotsubo syndrome (TTS) is currently limited, which is why we chose to investigate this parameter in affected patients.
SUBJECTS AND METHODS
Patients with TTS (n = 51), acute coronary syndrome (ACS; n = 29), and controls (n = 58) were retrospectively investigated. Laboratory and echocardiographic parameters including TI were analyzed for their ability to discriminate TTS in the total study cohort.
RESULTS
TI was the highest, and thus most pathological, in patients with TTS (median 0.516 vs. ACS: 0.355 vs. control: 0.313, p < 0.0001) and showed the best discriminatory ability for TTS (AUC: 0.836, p < 0.0001). A cut-off for diagnosis of TTS was calculated at ≥0.418 (specificity: 83.5% and sensitivity: 74.0%) by means of the Youden index.
CONCLUSION
The discriminatory ability of TI was better than that of other echocardiographic parameters such as LV systolic function. Due to the simple, fast, and inexpensive way of calculating TI, diagnostic workup with conventional parameters could be complemented by TI in patients with suspected TTS.
Identifiants
pubmed: 36572016
pii: 000528639
doi: 10.1159/000528639
pmc: PMC10267490
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-15Informations de copyright
© 2022 The Author(s). Published by S. Karger AG, Basel.
Références
N Engl J Med. 2015 Dec 31;373(27):2688
pubmed: 26716926
Indian Heart J. 2018 Jan - Feb;70(1):165-174
pubmed: 29455773
Eur Heart J. 2018 Jun 7;39(22):2047-2062
pubmed: 29850820
J Echocardiogr. 2016 Mar;14(1):13-20
pubmed: 26694809
J Am Soc Echocardiogr. 2002 Sep;15(9):864-8
pubmed: 12221401
N Engl J Med. 2015 Sep 3;373(10):929-38
pubmed: 26332547
Stat Med. 2013 Aug 30;32(19):3388-414
pubmed: 23508673
Am J Cardiol. 1998 Nov 1;82(9):1071-6
pubmed: 9817484
Eur Heart J. 2000 Nov;21(22):1888-95
pubmed: 11052862
Eur Heart J Acute Cardiovasc Care. 2020 Oct;9(7):711-720
pubmed: 32508142
Med Arh. 2011;65(5):287-90
pubmed: 22073853
Eur Heart J. 2018 Jun 7;39(22):2032-2046
pubmed: 29850871
Eur Heart J. 2018 Jan 7;39(2):119-177
pubmed: 28886621
Int J Biostat. 2019 Apr 3;15(1):
pubmed: 30943172
J Cardiol. 1995 Dec;26(6):357-66
pubmed: 8558414
Clin Auton Res. 2018 Feb;28(1):53-65
pubmed: 28917022
Eur J Heart Fail. 2017 Aug;19(8):1036-1042
pubmed: 27928880
Hellenic J Cardiol. 2009 Jan-Feb;50(1):60-5
pubmed: 19196622
Eur Heart J. 2011 Feb;32(4):404-11
pubmed: 21169615
Eur Heart J. 2021 Apr 7;42(14):1289-1367
pubmed: 32860058
J Cardiovasc Echogr. 2021 Jan-Mar;31(1):11-16
pubmed: 34221880
Hellenic J Cardiol. 2005 Jan-Feb;46(1):52-8
pubmed: 15807396
Med Sci Monit. 2011 Jun;17(6):RA135-47
pubmed: 21629203
J Cardiovasc Dev Dis. 2022 Aug 22;9(8):
pubmed: 36005447
Eur Heart J. 2014 Apr;35(15):999-1006
pubmed: 24046434
Front Cardiovasc Med. 2020 Dec 04;7:579567
pubmed: 33344515
J Geriatr Cardiol. 2014 Jun;11(2):171-3
pubmed: 25009569
Int J Cardiol. 2019 Feb 1;276:1-7
pubmed: 30413307
Hellenic J Cardiol. 2005 Jan-Feb;46(1):35-42
pubmed: 15807393