From information to physics to biology.

Commentary to "The gene: An appraisal" by Keith Baverstock. PBMB, Volume 164, September 2021, Pages 46-62. NOTE: this short and informal commentary constructively criticizes the very interesting approach in the paper by a brief survey of the work that a few of us develop since several years. I will first recall the very pertinent critique of the Modern Synthesis and the genocentric approach presented in the paper, then suggest a methodological (and theoretical) critique of the approach by K. Baverstock and hint to alternatives paths that are compatible, but "extend" the physics for biology presented by the author. The purposes and the space allowed force a limited number of references and technical details. These may be found in the references contained in the few papers quoted below that are not the most nor the only representative contributions to the that work, but are inserted as a source of references or as synthetic presentations of our views.

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.