Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study.
5-HT1B
cognition
healthy volunteers
positron emission tomography
serotonin
Journal
The international journal of neuropsychopharmacology
ISSN: 1469-5111
Titre abrégé: Int J Neuropsychopharmacol
Pays: England
ID NLM: 9815893
Informations de publication
Date de publication:
17 04 2023
17 04 2023
Historique:
received:
11
10
2022
accepted:
23
12
2022
medline:
19
4
2023
pubmed:
28
12
2022
entrez:
27
12
2022
Statut:
ppublish
Résumé
The serotonin system has been implicated in several psychiatric disorders. All major psychiatric disorders are associated with cognitive impairment, but treatment improving cognitive deficits is lacking, partly due to limited understanding of the neurobiology of cognitive functioning. Several markers for the serotonin system have been associated with cognitive functions. Our research group previously has reported a positive correlation between serotonin (5-HT1B) receptor availability in the dorsal brainstem and visuospatial memory in a pilot study of healthy individuals. Here, we aim to replicate our previous finding in a larger group of healthy volunteers as well as to investigate putative associations between 5-HT1B receptor availability and other cognitive domains. Forty-three healthy individuals were examined with positron emission tomography using the 5-HT1B receptor radioligand [11C]AZ10419369 and a visuospatial memory test to replicate our previous finding as well as tests of verbal fluency, cognitive flexibility, reaction time, and planning ability to explore other domains potentially associated with the serotonin system. Replication analysis revealed no statistically significant association between 5-HT1B receptor availability in the dorsal brainstem and visuospatial memory performance. Exploratory analyses showed age-adjusted correlations between 5-HT1B receptor availability in whole brain gray matter and specific brain regions, and number of commission errors, reaction time, and planning ability. Higher 5-HT1B receptor availability was associated with more false-positive responses and faster reaction time but lower performance in planning and problem-solving. These results corroborate previous research supporting an important role of the serotonin system in impulsive behavior and planning ability.
Sections du résumé
BACKGROUND
The serotonin system has been implicated in several psychiatric disorders. All major psychiatric disorders are associated with cognitive impairment, but treatment improving cognitive deficits is lacking, partly due to limited understanding of the neurobiology of cognitive functioning. Several markers for the serotonin system have been associated with cognitive functions. Our research group previously has reported a positive correlation between serotonin (5-HT1B) receptor availability in the dorsal brainstem and visuospatial memory in a pilot study of healthy individuals. Here, we aim to replicate our previous finding in a larger group of healthy volunteers as well as to investigate putative associations between 5-HT1B receptor availability and other cognitive domains.
METHODS
Forty-three healthy individuals were examined with positron emission tomography using the 5-HT1B receptor radioligand [11C]AZ10419369 and a visuospatial memory test to replicate our previous finding as well as tests of verbal fluency, cognitive flexibility, reaction time, and planning ability to explore other domains potentially associated with the serotonin system.
RESULTS
Replication analysis revealed no statistically significant association between 5-HT1B receptor availability in the dorsal brainstem and visuospatial memory performance. Exploratory analyses showed age-adjusted correlations between 5-HT1B receptor availability in whole brain gray matter and specific brain regions, and number of commission errors, reaction time, and planning ability.
CONCLUSIONS
Higher 5-HT1B receptor availability was associated with more false-positive responses and faster reaction time but lower performance in planning and problem-solving. These results corroborate previous research supporting an important role of the serotonin system in impulsive behavior and planning ability.
Identifiants
pubmed: 36573320
pii: 6961177
doi: 10.1093/ijnp/pyac084
pmc: PMC10109060
doi:
Substances chimiques
Receptor, Serotonin, 5-HT1B
0
Carbon-11
0
Carbon Radioisotopes
0
Serotonin
333DO1RDJY
Morpholines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-248Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.
Références
Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1639-50
pubmed: 19437012
Neurosci Lett. 2003 Feb 20;338(1):1-4
pubmed: 12565126
Psychiatry Res Neuroimaging. 2017 Sep 30;267:15-21
pubmed: 28688337
Neuroscience. 1981;6(4):557-618
pubmed: 7017455
J Psychiatr Res. 2017 Sep;92:199-204
pubmed: 28502766
Psychol Med. 2013 Mar;43(3):471-81
pubmed: 22831756
Nat Neurosci. 1998 Jun;1(2):132-7
pubmed: 10195128
Eur Psychiatry. 2015 Feb;30(2):193-7
pubmed: 25447350
Psychol Med. 2014 Jul;44(10):2029-40
pubmed: 24168753
Psychiatry Res Neuroimaging. 2016 Jul 30;253:36-42
pubmed: 27269199
Can J Neurol Sci. 1986 Nov;13(4 Suppl):420-3
pubmed: 3491663
Psychol Addict Behav. 2013 Jun;27(2):380-92
pubmed: 23586456
Psychopharmacology (Berl). 2002 Aug;163(1):42-53
pubmed: 12185399
Psychopharmacology (Berl). 1995 Sep;121(2):222-30
pubmed: 8545528
Neuron. 2015 May 6;86(3):813-26
pubmed: 25892302
Psychopharmacology (Berl). 2011 Feb;213(2-3):573-81
pubmed: 20623110
Psychopharmacology (Berl). 2002 Dec;164(4):385-91
pubmed: 12457268
Int J Neuropsychopharmacol. 2013 Aug;16(7):1577-86
pubmed: 23351590
Int J Neuropsychopharmacol. 2009 Jul;12(6):783-92
pubmed: 19126263
Psychiatry Res. 2003 Dec 1;121(2):179-84
pubmed: 14656452
Eur J Pharmacol. 1975 Mar;31(1):81-93
pubmed: 1168580
J Cereb Blood Flow Metab. 2022 Apr;42(4):630-641
pubmed: 34644198
Neuroimage. 2008 Jul 1;41(3):1075-85
pubmed: 18434202
Psychol Bull. 2013 Sep;139(5):1148-72
pubmed: 23379963
Transl Psychiatry. 2021 May 10;11(1):264
pubmed: 33972499
Nat Rev Drug Discov. 2012 Feb 01;11(2):141-68
pubmed: 22293568
Neuroimage. 2014 Dec;103:303-308
pubmed: 25255943
Neuropharmacology. 1999 Aug;38(8):1083-152
pubmed: 10462127
J Affect Disord. 2017 Jan 01;207:359-366
pubmed: 27744224
Cephalalgia. 2002 May;22(4):271-81
pubmed: 12100089
J Med Chem. 2011 May 12;54(9):3206-21
pubmed: 21486038
Eur Neuropsychopharmacol. 2016 Mar;26(3):570-7
pubmed: 26775837
Neuropsychology. 2017 Jan;31(1):52-72
pubmed: 27732039
Science. 1994 Sep 23;265(5180):1875-8
pubmed: 8091214
Curr Drug Targets. 2009 Nov;10(11):1118-38
pubmed: 19702551
Psychopharmacology (Berl). 2007 Feb;190(3):391-400
pubmed: 17124621
Arch Gen Psychiatry. 2011 Sep;68(9):892-900
pubmed: 21893657
Transl Psychiatry. 2020 Jun 1;10(1):159
pubmed: 32475989
Brain Res. 2001 Oct 5;915(1):47-57
pubmed: 11578619
Twin Res Hum Genet. 2009 Apr;12(2):158-68
pubmed: 19335186
Psychopharmacology (Berl). 2011 Feb;213(2-3):547-53
pubmed: 20480149
Psychol Psychother. 2011 Jun;84(2):141-50
pubmed: 22903853
Eur J Pharmacol. 2010 Jan 10;626(1):83-6
pubmed: 19835870
Neuropsychopharmacology. 2003 Jan;28(1):153-62
pubmed: 12496952
Neuroimage. 2017 Jul 15;155:344-353
pubmed: 28419852
Int Clin Psychopharmacol. 1992 Spring;7(1):3-12
pubmed: 1624755
Neuropsychopharmacology. 2019 Sep;44(10):1706-1713
pubmed: 31216565
J Psychopharmacol. 2007 Jul;21(5):477-85
pubmed: 17092965
Am J Psychiatry. 2003 Feb;160(2):334-40
pubmed: 12562581
Lancet Psychiatry. 2016 May;3(5):425-35
pubmed: 26995298
Acta Psychiatr Scand Suppl. 2007;(433):44-9
pubmed: 17280570
Synapse. 2015 Jul;69(7):365-74
pubmed: 25914348
Psychopharmacology (Berl). 2018 May;235(5):1317-1334
pubmed: 29546551
Front Psychiatry. 2019 Nov 06;10:771
pubmed: 31780961
Psychiatry Clin Neurosci. 2019 Feb;73(2):70-76
pubmed: 30393945
Neuroimage. 2018 Feb 1;166:79-85
pubmed: 29061526
Neuroimage. 2006 Oct 1;32(4):1690-708
pubmed: 16859930
Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):301-7
pubmed: 24006152
Psychiatry Res. 2014 Aug 30;223(2):164-70
pubmed: 24916155
Biol Psychiatry. 2010 May 1;67(9):800-3
pubmed: 20172504
Psychopharmacology (Berl). 2006 Apr;185(3):389-94
pubmed: 16541245
Neuropharmacology. 2008 Jun;54(7):1041-50
pubmed: 18394658
Acta Physiol Scand. 1964 Mar;60:293-4
pubmed: 14131843
Ann Clin Psychiatry. 2007 Oct-Dec;19(4):265-77
pubmed: 18058284
J Int Neuropsychol Soc. 2017 Oct;23(9-10):818-831
pubmed: 29198280