Imaging Non-alcoholic Fatty Liver Disease Model Using H-1 and F-19 MRI.
Fatty liver disease
Fluorine-19
In vivo
Inflammation
MRI
Macrophage
NAFLD
NASH
Nanoemulsion
Perfluorocarbon
Steatohepatitis
Steatosis
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
21
03
2022
accepted:
15
12
2022
revised:
09
12
2022
medline:
12
5
2023
pubmed:
28
12
2022
entrez:
27
12
2022
Statut:
ppublish
Résumé
We explore the use of intravenously delivered perfluorocarbon (PFC) nanoemulsion and C57BL/6 mice were fed standard or high-fat diet (HFD) for 6 weeks to induce NAFLD. Significant increases in liver volume, PDFF, and total PFC uptake were noted in HFD mice compared to Std diet mice. Liver fluorine density and T We demonstrated longitudinal quantification of multiple MRI biomarkers of disease in NAFLD mice. The changes in liver PFC uptake in HFD mice were compared with healthy mice that suggests that
Identifiants
pubmed: 36575339
doi: 10.1007/s11307-022-01798-y
pii: 10.1007/s11307-022-01798-y
pmc: PMC10246777
mid: NIHMS1864197
doi:
Substances chimiques
Protons
0
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-449Subventions
Organisme : NCI NIH HHS
ID : R01 CA134633
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB024015
Pays : United States
Organisme : NIH HHS
ID : R01-CA139579
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to World Molecular Imaging Society.
Références
Sanyal AJ (2019) Past, present and future perspectives in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. https://doi.org/10.1038/s41575-019-0144-8
doi: 10.1038/s41575-019-0144-8
pubmed: 31024089
Khov N, Sharma A, Riley TR (2014) Bedside ultrasound in the diagnosis of nonalcoholic fatty liver disease. World J Gastroenterol. https://doi.org/10.3748/wjg.v20.i22.6821
doi: 10.3748/wjg.v20.i22.6821
pubmed: 24944472
pmcid: 4051921
Zhang YN, Fowler KJ, Boehringer AS, Montes V, Schlein AN, Covarrubias Y, Wolfson T, Hong CW, Valasek MA, Andre MP, Loomba R, Sirlin CB (2022) Comparative diagnostic performance of ultrasound shear wave elastography and magnetic resonance elastography for classifying fibrosis stage in adults with biopsy-proven nonalcoholic fatty liver disease. Eur Radiol. https://doi.org/10.1007/s00330-021-08369-9
doi: 10.1007/s00330-021-08369-9
pubmed: 36580095
pmcid: 10121518
Caussy C, Johansson L (2020) Magnetic resonance-based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Endocrinol Diabetes Metab J. https://doi.org/10.1002/edm2.134
doi: 10.1002/edm2.134
Hernando D, Sharma SD, AliyariGhasabeh M, Alvis BD, Arora SS, Hamilton G et al (2017) Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat–water phantom. Magn Reson Med. https://doi.org/10.1002/mrm.26228
doi: 10.1002/mrm.26228
pubmed: 28862351
pmcid: 5821578
Reeder SB, Sirlin CB (2010) Quantification of liver fat with magnetic resonance imaging. Magn Reson Imaging Clin N Am. https://doi.org/10.1016/j.mric.2010.08.013
doi: 10.1016/j.mric.2010.08.013
pubmed: 21094445
pmcid: 3430384
Reeder SB, Cruite I, Hamilton G, Sirlin CB (2011) Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. https://doi.org/10.1002/jmri.22580
doi: 10.1002/jmri.22580
pubmed: 22127834
pmcid: 3292661
Wong VWS, Adams LA, de Lédinghen V, Wong GLH, Sookoian S (2018) Noninvasive biomarkers in NAFLD and NASH — current progress and future promise. Nat Rev Gastroenterol Hepatol. https://doi.org/10.1038/s41575-018-0014-9
doi: 10.1038/s41575-018-0014-9
pubmed: 29844588
Bray TJP, Chouhan MD, Punwani S, Bridge A, Hall-Craggs MA (2018) Fat fraction mapping using magnetic resonance imaging: insight into pathophysiology. Br J Radiol. https://doi.org/10.1259/bjr.20170344
doi: 10.1259/bjr.20170344
pubmed: 28936896
Parthasarathy G, Revelo X, Malhi H (2020) Pathogenesis of nonalcoholic steatohepatitis: an overview. Hepatol Commun. https://doi.org/10.1002/hep4.1479
doi: 10.1002/hep4.1479
pubmed: 32258944
pmcid: 7109346
Reid DT, Reyes JL, McDonald BA, Vo T, Reimer RA, Eksteen B (2016) Kupffer cells undergo fundamental changes during the development of experimental NASH and are critical in initiating liver damage and inflammation. PLoS ONE. https://doi.org/10.1371/journal.pone.0159524
doi: 10.1371/journal.pone.0159524
pubmed: 28006827
pmcid: 5179261
Kadayakkara DK, Ranganathan S, Bin Young W, Ahrens ET (2012) Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI. Lab Investig. https://doi.org/10.1038/labinvest.2012.7
doi: 10.1038/labinvest.2012.7
pubmed: 22330343
Khurana A, Chapelin F, Xu H, Acevedo JR, Molinolo A, Nguyen Q et al (2018) Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. https://doi.org/10.1002/mrm.26854
doi: 10.1002/mrm.26854
pubmed: 28748562
Balducci A, Helfer BM, Ahrens ET, Ohanlon CF, Wesa AK (2012) Visualizing arthritic inflammation and therapeutic response by fluorine-19 magnetic resonance imaging (19F MRI). J Inflamm (United Kingdom). https://doi.org/10.1186/1476-9255-9-24.10.1111/cts.12735
doi: 10.1186/1476-9255-9-24.10.1111/cts.12735
Reeder SB (2013) Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis. Hepatology. https://doi.org/10.1002/hep.26543
doi: 10.1002/hep.26543
pubmed: 23744793
Chapelin F, Capitini CM, Ahrens ET (2018) Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer. J Immunother Cancer. https://doi.org/10.1186/s40425-018-0416-9
doi: 10.1186/s40425-018-0416-9
pubmed: 30305175
pmcid: 6180584
Srinivas M, Heerschap A, Ahrens ET, Figdor CG, de Vries IJM (2010) 19F MRI for quantitative in vivo cell tracking. Trends Biotechnol. https://doi.org/10.1016/j.tibtech.2010.04.002
doi: 10.1016/j.tibtech.2010.04.002
pubmed: 20427096
pmcid: 2902646
Zhong X, Nickel MD, Kannengiesser SAR, Dale BM, Kiefer B, Bashir MR (2014) Liver fat quantification using a multi-step adaptive fitting approach with multi-echo GRE imaging. Magn Reson Med 72:1353–1365. https://doi.org/10.1002/MRM.25054
doi: 10.1002/MRM.25054
pubmed: 24323332
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW et al (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. https://doi.org/10.1002/hep.20701
doi: 10.1002/hep.20701
pubmed: 15915461
Staal AHJ, Becker K, Tagit O, van Riessen NK, Koshkina O, Veltien A et al (2020) In vivo clearance of 19F MRI imaging nanocarriers is strongly influenced by nanoparticle ultrastructure. Biomaterials 261:120307. https://doi.org/10.1016/J.BIOMATERIALS.2020.120307
doi: 10.1016/J.BIOMATERIALS.2020.120307
pubmed: 32927288
Ahrens ET, Bin Young W, Xu H, Pusateri LK (2021) Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance. Biotechniques. https://doi.org/10.2144/000113652
doi: 10.2144/000113652