CO
Biomarker
CO2 challenge
Clinical trial
Exposure therapy
Generalized anxiety disorder
Obsessive–compulsive disorder
Orexin
Panic disorder
Posttraumatic stress disorder
Social anxiety disorder
Journal
BMC psychiatry
ISSN: 1471-244X
Titre abrégé: BMC Psychiatry
Pays: England
ID NLM: 100968559
Informations de publication
Date de publication:
27 12 2022
27 12 2022
Historique:
received:
21
11
2022
accepted:
15
12
2022
entrez:
27
12
2022
pubmed:
28
12
2022
medline:
30
12
2022
Statut:
epublish
Résumé
Exposure-based therapy is an effective first-line treatment for anxiety-, obsessive-compulsive, and trauma- and stressor-related disorders; however, many patients do not improve, resulting in prolonged suffering and poorly used resources. Basic research on fear extinction may inform the development of a biomarker for the selection of exposure-based therapy. Growing evidence links orexin system activity to deficits in fear extinction and we have demonstrated that reactivity to an inhaled carbon dioxide (CO We will assess CO Representing a necessary stage in translating basic research, this investigation addresses an important public health issue by testing an accessible clinical assessment strategy that may lead to a more effective treatment selection (personalized medicine) for patients with anxiety- and fear-related disorders, and enhanced understanding of the mechanisms governing exposure-based therapy. ClinicalTrials.gov Identifier: NCT05467683 (20/07/2022).
Sections du résumé
BACKGROUND
Exposure-based therapy is an effective first-line treatment for anxiety-, obsessive-compulsive, and trauma- and stressor-related disorders; however, many patients do not improve, resulting in prolonged suffering and poorly used resources. Basic research on fear extinction may inform the development of a biomarker for the selection of exposure-based therapy. Growing evidence links orexin system activity to deficits in fear extinction and we have demonstrated that reactivity to an inhaled carbon dioxide (CO
METHODS
We will assess CO
DISCUSSION
Representing a necessary stage in translating basic research, this investigation addresses an important public health issue by testing an accessible clinical assessment strategy that may lead to a more effective treatment selection (personalized medicine) for patients with anxiety- and fear-related disorders, and enhanced understanding of the mechanisms governing exposure-based therapy.
TRIAL REGISTRATION
ClinicalTrials.gov Identifier: NCT05467683 (20/07/2022).
Identifiants
pubmed: 36575425
doi: 10.1186/s12888-022-04478-x
pii: 10.1186/s12888-022-04478-x
pmc: PMC9793569
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Orexins
0
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT05467683']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
831Subventions
Organisme : NIMH NIH HHS
ID : R01 MH125949
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH125951
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 19;373(1742):
pubmed: 29352025
Behav Res Ther. 2007 Sep;45(9):1987-2001
pubmed: 17659253
Psychopharmacology (Berl). 2019 Jan;236(1):99-110
pubmed: 30218131
Behav Ther. 2012 Sep;43(3):641-51
pubmed: 22697451
J Trauma Stress. 2018 Oct;31(5):753-763
pubmed: 30338573
Biol Psychiatry. 2006 Aug 15;60(4):319-21
pubmed: 16919521
Int J Methods Psychiatr Res. 2012 Dec;21(4):258-72
pubmed: 23148016
Int J Neuropsychopharmacol. 2017 Aug 1;20(8):654-659
pubmed: 28453642
Arch Intern Med. 2006 May 22;166(10):1092-7
pubmed: 16717171
Trends Neurosci. 2015 Sep;38(9):550-9
pubmed: 26216377
Behav Ther. 2011 Dec;42(4):676-88
pubmed: 22035996
J Psychiatr Res. 2011 Jul;45(7):989-93
pubmed: 21324483
Eur Psychiatry. 2009 Jun;24(5):297-306
pubmed: 19200694
Behav Res Ther. 2019 Sep;120:103412
pubmed: 31233922
Arch Gen Psychiatry. 2004 Oct;61(10):1005-13
pubmed: 15466674
Am J Psychiatry. 2011 Dec;168(12):1266-77
pubmed: 22193671
Behav Res Ther. 2006 May;44(5):657-65
pubmed: 16038874
Clin Psychol Rev. 2015 Dec;42:72-82
pubmed: 26319194
J Clin Psychol. 2016 Oct;72(10):1099-111
pubmed: 27228035
J Anxiety Disord. 2012 Apr;26(3):468-79
pubmed: 22366534
Behav Res Ther. 2002 Aug;40(8):931-45
pubmed: 12186356
Neuropsychopharmacology. 2012 Jul;37(8):1911-22
pubmed: 22453138
Psychol Med. 2020 Apr;50(5):727-736
pubmed: 32204741
Psychol Addict Behav. 2011 Dec;25(4):745-9
pubmed: 21823763
J Psychiatr Res. 2021 Nov;143:508-515
pubmed: 33250190
J Abnorm Psychol. 1992 Aug;101(3):538-52
pubmed: 1500611
J Appl Physiol (1985). 2007 Nov;103(5):1772-9
pubmed: 17717124
JAMA. 2000 May 17;283(19):2529-36
pubmed: 10815116
Psychol Med. 2019 Oct;49(14):2330-2341
pubmed: 30392475
PLoS One. 2013 Aug 16;8(8):e71079
pubmed: 23976980
Depress Anxiety. 2002;15(4):183-5
pubmed: 12112724
Arch Gen Psychiatry. 2005 Jun;62(6):617-27
pubmed: 15939839
J Anxiety Disord. 1997 May-Jun;11(3):221-40
pubmed: 9220298
Behav Res Ther. 1996 Aug;34(8):675-84
pubmed: 8870295
Nat Neurosci. 2014 Oct;17(10):1298-303
pubmed: 25254979
PM R. 2013 Sep;5(9):791-4
pubmed: 24054854
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10685-90
pubmed: 17563364
Cogn Behav Ther. 2017 Nov;46(6):459-477
pubmed: 28641047
J Child Psychol Psychiatry. 2016 Jul;57(7):869-76
pubmed: 26871483
J Behav Ther Exp Psychiatry. 2000 Jun;31(2):73-86
pubmed: 11132119
Cogn Behav Pract. 2019 Feb;26(1):186-200
pubmed: 31787834
Behav Res Ther. 2022 Jun;153:104086
pubmed: 35462242
Peptides. 2017 Feb;88:55-61
pubmed: 27988352
Transl Psychiatry. 2020 Sep 7;10(1):308
pubmed: 32895369
Clin Psychol Rev. 2005 May;25(3):285-306
pubmed: 15792851
J Anxiety Disord. 2003;17(5):583-91
pubmed: 12941368
J Trauma Stress. 2015 Dec;28(6):489-98
pubmed: 26606250
Clin Psychol Rev. 2016 Nov;49:1-15
pubmed: 27475477
Depress Anxiety. 2009;26(1):22-7
pubmed: 18781661
J Anxiety Disord. 2015 Jun;33:90-4
pubmed: 26037493
Neuron. 2014 Jan 22;81(2):428-37
pubmed: 24462103
Int J Psychophysiol. 2017 Nov;121:63-71
pubmed: 28893566
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
pubmed: 9419374
Cognit Ther Res. 2013 Apr;37(2):363-367
pubmed: 32773909
J Clin Psychiatry. 1999 Jun;60(6):379-84
pubmed: 10401916
Transl Psychiatry. 2016 Sep 06;6(9):e885
pubmed: 27598969
J Psychopharmacol. 2012 Apr;26(4):479-86
pubmed: 22228835
Behav Ther. 2019 Jan;50(1):165-176
pubmed: 30661557
Res Psychother. 2019 Dec 19;22(3):379
pubmed: 32913807
J Consult Clin Psychol. 1995 Oct;63(5):754-65
pubmed: 7593868
Annu Rev Psychol. 2017 Jan 3;68:601-625
pubmed: 27687116
Behav Res Ther. 2018 Sep;108:40-44
pubmed: 29981937
PLoS One. 2007 Oct 03;2(10):e987
pubmed: 17912364
Behav Res Ther. 2002 Jun;40(6):701-15
pubmed: 12051488
Arch Gen Psychiatry. 1988 Jan;45(1):43-52
pubmed: 3122696
Sci Rep. 2020 Mar 9;10(1):4288
pubmed: 32152429
Am J Psychiatry. 1995 Jan;152(1):85-9
pubmed: 7802126
J Behav Ther Exp Psychiatry. 2003 Jun;34(2):161-70
pubmed: 12899898
Int J Biostat. 2016 May 1;12(1):305-32
pubmed: 27227726
Mol Psychiatry. 2007 Feb;12(2):120-50
pubmed: 17160066
Physiol Behav. 2017 Sep 1;178:93-102
pubmed: 27746261
Am J Psychiatry. 2005 Jan;162(1):151-61
pubmed: 15625214
JAMA Psychiatry. 2019 Feb 1;76(2):117-126
pubmed: 30516797
J Psychiatr Res. 2011 Feb;45(2):262-8
pubmed: 20609450
Neurobiol Learn Mem. 2016 Feb;128:7-16
pubmed: 26690954
Psychiatry Res. 1997 Jun 16;71(1):41-8
pubmed: 9247980
Am J Health Syst Pharm. 2018 Jun 15;75(12):876-885
pubmed: 29720459
Neuroscience. 2017 Mar 27;346:434-436
pubmed: 28188857
Arch Gen Psychiatry. 2005 Jun;62(6):593-602
pubmed: 15939837
Depress Anxiety. 2017 Mar;34(3):257-266
pubmed: 27921340
Psychol Med. 2007 Oct;37(10):1493-502
pubmed: 17493294
Med Care. 2005 Dec;43(12):1164-70
pubmed: 16299426
J Behav Ther Exp Psychiatry. 2010 Dec;41(4):365-72
pubmed: 20430368
Stat Med. 1983 Apr-Jun;2(2):243-51
pubmed: 6359318
Expert Rev Mol Med. 2008 Oct 02;10:e28
pubmed: 18828950
Lancet Psychiatry. 2018 Dec;5(12):1032-1042
pubmed: 30385214
J Consult Clin Psychol. 2005 Oct;73(5):953-64
pubmed: 16287395
Eur Neuropsychopharmacol. 2011 Sep;21(9):655-79
pubmed: 21896369
Cell. 1998 Feb 20;92(4):573-85
pubmed: 9491897
J Psychopharmacol. 2011 Jan;25(1):43-51
pubmed: 20233897
Behav Res Ther. 1985;23(1):35-44
pubmed: 3985915
Am J Psychiatry. 2007 Jul;164(7 Suppl):5-53
pubmed: 17849776
J Clin Psychol. 2013 Jun;69(6):630-45
pubmed: 23381685
Neuropsychopharmacology. 2014 Nov;39(12):2732-41
pubmed: 24930888
Am J Psychiatry. 1987 Aug;144(8):1080-2
pubmed: 3111280
Psychol Serv. 2021 Nov;18(4):606-618
pubmed: 32658509
J Anxiety Disord. 2020 Dec;76:102309
pubmed: 33002756
J Clin Psychiatry. 2008 Mar;69(3):418-24
pubmed: 18278989
Assessment. 2011 Sep;18(3):263-83
pubmed: 21697139
Nat Commun. 2013;4:1547
pubmed: 23462990
Nat Rev Neurosci. 2014 Nov;15(11):719-31
pubmed: 25301357
Depress Anxiety. 2018 Jun;35(6):502-514
pubmed: 29451967
Psychol Assess. 2007 Jun;19(2):176-88
pubmed: 17563199
Curr Opin Psychiatry. 2019 Jan;32(1):1-6
pubmed: 30480619
Respir Physiol Neurobiol. 2009 May 15;166(3):184-6
pubmed: 19442935
Front Endocrinol (Lausanne). 2018 Dec 05;9:710
pubmed: 30568633
J Anxiety Disord. 2011 Jun;25(5):645-53
pubmed: 21474277
J Abnorm Psychol. 1996 Aug;105(3):446-54
pubmed: 8772015
Psychol Assess. 2014 Mar;26(1):35-45
pubmed: 24059474
J Autism Dev Disord. 2017 Dec;47(12):3949-3958
pubmed: 27405445
J Trauma Stress. 2010 Dec;23(6):663-73
pubmed: 21171126
Med Res Rev. 2015 Jan;35(1):152-97
pubmed: 25044006
J Psychiatr Res. 2018 Jan;96:260-264
pubmed: 29128558
Behav Res Ther. 2008 Jan;46(1):5-27
pubmed: 18005936
Behav Res Ther. 1986;24(1):1-8
pubmed: 3947307
Transl Psychiatry. 2019 Feb 4;9(1):75
pubmed: 30718541
Clin Psychol Rev. 2008 Jan;28(1):118-130
pubmed: 17531365
BMC Psychiatry. 2014;14 Suppl 1:S1
pubmed: 25081580
Neuropsychopharmacology. 2020 Feb;45(3):534-541
pubmed: 31352467
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7629-34
pubmed: 26100887
Clin Psychol Rev. 2001 Apr;21(3):375-400
pubmed: 11288606