Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond.
chloroplast
chloroplast unfolded protein response
genomes uncoupled
gun
retrograde signaling
subcellular metabolomes
subcellular proteomes
Journal
Plant communications
ISSN: 2590-3462
Titre abrégé: Plant Commun
Pays: China
ID NLM: 101769147
Informations de publication
Date de publication:
09 01 2023
09 01 2023
Historique:
received:
15
10
2022
revised:
05
12
2022
accepted:
22
12
2022
pubmed:
29
12
2022
medline:
13
1
2023
entrez:
28
12
2022
Statut:
ppublish
Résumé
Plastids communicate their developmental and physiological status to the nucleus via retrograde signaling, allowing nuclear gene expression to be adjusted appropriately. Signaling during plastid biogenesis and responses of mature chloroplasts to environmental changes are designated "biogenic" and "operational" controls, respectively. A prominent example of the investigation of biogenic signaling is the screen for gun (genomes uncoupled) mutants. Although the first five gun mutants were identified 30 years ago, the functions of GUN proteins in retrograde signaling remain controversial, and that of GUN1 is hotly disputed. Here, we provide background information and critically discuss recently proposed concepts that address GUN-related signaling and some novel gun mutants. Moreover, considering heme as a candidate in retrograde signaling, we revisit the spatial organization of heme biosynthesis and export from plastids. Although this review focuses on GUN pathways, we also highlight recent progress in the identification and elucidation of chloroplast-derived signals that regulate the acclimation response in green algae and plants. Here, stress-induced accumulation of unfolded/misassembled chloroplast proteins evokes a chloroplast-specific unfolded protein response, which leads to changes in the expression levels of nucleus-encoded chaperones and proteases to restore plastid protein homeostasis. We also address the importance of chloroplast-derived signals for activation of flavonoid biosynthesis leading to production of anthocyanins during stress acclimation through sucrose non-fermenting 1-related protein kinase 1. Finally, a framework for identification and quantification of intercompartmental signaling cascades at the proteomic and metabolomic levels is provided, and we discuss future directions of dissection of organelle-nucleus communication.
Identifiants
pubmed: 36575799
pii: S2590-3462(22)00358-3
doi: 10.1016/j.xplc.2022.100511
pmc: PMC9860301
pii:
doi:
Substances chimiques
Arabidopsis Proteins
0
Anthocyanins
0
Heme
42VZT0U6YR
GUN1 protein, Arabidopsis
0
DNA-Binding Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100511Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
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