Secondary metabolites from the Mongolian medicine Lomatogonium carinthiacum.
Gentianaceae
Immunosuppressive activity
Lomatogonium carinthiacum
Monoterpenoid alkaloids
Monoterpenoids
Sesquiterpenoids
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
02
12
2022
revised:
20
12
2022
accepted:
22
12
2022
pubmed:
29
12
2022
medline:
11
2
2023
entrez:
28
12
2022
Statut:
ppublish
Résumé
Systematic phytochemical investigation on the Mongolian medicinal herb Lomatogonium carinthiacum led to the isolation of 12 monoterpenoids including three new secoiridoids (1, 2 and 4) and one new iridoid glycoside (13), one new monoterpenoid alkaloid (3), and three new sesquiterpenoids (14-16). Comprehensive spectroscopic analysis (including 1D and 2D NMR, and HRESIMS) and quantum chemistry computations (including ECD and NMR calculations) were applied to elucidate their structures. Weak immunosuppressive activities were observed for the new isolates via inhibiting T cell proliferation and cytokine IFN-γ secretion in vitro.
Identifiants
pubmed: 36577456
pii: S0367-326X(22)00280-5
doi: 10.1016/j.fitote.2022.105402
pii:
doi:
Substances chimiques
Glycosides
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105402Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.