Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry.
Alzheimer's disease
Cardiometabolic disease
Dementia
Life-course approach
Twin study
Vascular dementia
Journal
European heart journal
ISSN: 1522-9645
Titre abrégé: Eur Heart J
Pays: England
ID NLM: 8006263
Informations de publication
Date de publication:
14 02 2023
14 02 2023
Historique:
received:
16
05
2022
revised:
01
11
2022
accepted:
29
11
2022
pubmed:
29
12
2022
medline:
16
2
2023
entrez:
28
12
2022
Statut:
ppublish
Résumé
Cardiometabolic diseases (CMDs), including diabetes, heart disease, and stroke, are established risk factors for dementia, but their combined impact has been investigated only recently. This study aimed to examine the association between mid- and late-life cardiometabolic multimorbidity and dementia and explore the role of genetic background in this association. Within the Swedish Twin Registry, 17 913 dementia-free individuals aged ≥60 were followed for 18 years. CMDs [including age of onset in mid (60) or late (≥60) life] and dementia were ascertained from medical records. Cardiometabolic multimorbidity was defined as having ≥2 CMDs. Cox regression was used to estimate the CMD-dementia association in (i) a classical cohort study design and (ii) a co-twin study design involving 356 monozygotic and dizygotic pairs. By comparing the strength of the association in the two designs, the contribution of genetic background was estimated. At baseline, 3,312 (18.5%) participants had 1 CMD and 839 (4.7%) had ≥2 CMDs. Over the follow-up period, 3,020 participants developed dementia. In the classic cohort design, the hazard ratio (95% confidence interval) of dementia was 1.42 (1.27-1.58) for 1 CMD and 2.10 (1.73-2.57) for ≥2 CMDs. Dementia risk was stronger with mid-life as opposed to late-life CMDs. In the co-twin design, the CMD-dementia association was attenuated among monozygotic [0.99 (0.50-1.98)] but not dizygotic [1.55 (1.15-2.09)] twins, suggesting that the association was in part due to genetic factors common to both CMDs and dementia. Cardiometabolic multimorbidity, particularly in mid-life, is associated with an increased risk of dementia. Genetic background may underpin this association.
Identifiants
pubmed: 36577740
pii: 6964658
doi: 10.1093/eurheartj/ehac744
pmc: PMC9925275
doi:
Types de publication
Twin Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
573-582Subventions
Organisme : Swedish Twin Registry
Organisme : Karolinska Institutet
Organisme : Swedish Research Council
ID : No. 2017-00641
Organisme : Swedish Council for Health Working Life and Welfare
ID : No. 2021-01826
Organisme : Swedish Research Council for Health, Working Life and Welfare
ID : No. 2021-01826
Organisme : Swedish National Graduate School
Organisme : Aging and Health
Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
Déclaration de conflit d'intérêts
Conflict of interest: None declared.
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