Distinct urinary progesterone metabolite profiles during the luteal phase.

Female Humans Progesterone Luteal Phase Pregnanediol / urine Luteinizing Hormone Glucuronides Menstrual Cycle
luteal phase menstrual cycle ovulation pregnanediol-3-glucuronide progesterone

Journal

Hormone molecular biology and clinical investigation
ISSN: 1868-1891
Titre abrégé: Horm Mol Biol Clin Investig
Pays: Germany
ID NLM: 101538885

Informations de publication

Date de publication:
01 Jun 2023
Historique:
received: 29 06 2022
accepted: 06 12 2022
medline: 3 7 2023
pubmed: 30 12 2022
entrez: 29 12 2022
Statut: epublish

Résumé

During normal menstrual cycles, serum levels of progesterone vary widely between cycles of same woman and between women. This study investigated the profiles of pregnanediol during the luteal phase. Data stemmed from a previous multicenter prospective observational study and concerned 107 women (who contributed 326 menstrual cycles). The study analyzed changes in observed cervical mucus discharge, various hormones in first morning urine, and serum progesterone. Transvaginal ultrasonography and cervical mucus helped identifying the day of ovulation. Changes in pregnanediol glucuronide levels during the luteal phase were examined and classified according to the length of that phase, a location parameter, and a scale parameter. Associations between nine pregnanediol glucuronide profiles and other hormone profiles were examined. Low periovulatory pregnanediol glucuronide levels and low periovulatory luteinizing hormone levels were associated with delayed increases in pregnanediol glucuronide after ovulation. That 'delayed increase profile' was more frequently associated with cycles with prolonged high LH levels than in cycles with rapid pregnanediol glucuronide increases. A 'plateau-like profile' during the luteal phase was associated with longer cycles, cycles with higher estrone-3-glucuronide and pregnanediol glucuronide during the preovulatory phase, and cycles with higher periovulatory pregnanediol glucuronide levels. Distinct profiles of urinary progesterone levels are displayed during the luteal phase. These profiles relate to early hormone changes during the menstrual cycle. In everyday clinical practice, these findings provide further evidence for recommending progesterone test seven days after the mucus peak day. The search for other correlations and associations is underway.

Identifiants

DOI: 10.1515/hmbci-2022-0065 PMID: 36578213
pubmed: 36578213
pii: hmbci-2022-0065
doi: 10.1515/hmbci-2022-0065
doi:

Substances chimiques

Progesterone 4G7DS2Q64Y
Pregnanediol JR3JD1Y22C
Luteinizing Hormone 9002-67-9
Glucuronides 0

Types de publication

Observational Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

137-144

Informations de copyright

© 2022 Walter de Gruyter GmbH, Berlin/Boston.

Références

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Auteurs

Saman Abdullah (S)

Department of Statistics and Information, College of Administration and Economics, University of Sulaimani, Sulaymaniyah, Iraq.
ORCID: 0000-0001-8182-0884

Thomas Bouchard (T)

Department of Family Medicine, University of Calgary, Calgary, AB, Canada.

René Leiva (R)

Bruyère Research Institute, CT Lamont Primary Health Care Research Centre, Ottawa, ON, Canada.
Department of Family Medicine, University of Ottawa, Ottawa, ON, Canada.

Hans Boehringer (H)

DCN Diagnostics, Carlsbad, CA, USA.

Jean Iwaz (J)

Pôle Santé Publique, Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France.
Université de Lyon, Lyon, France.
Université Lyon 1, Villeurbanne, France.
CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, Villeurbanne, France.

René Ecochard (R)

Pôle Santé Publique, Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France.
Université de Lyon, Lyon, France.
Université Lyon 1, Villeurbanne, France.
CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, Villeurbanne, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Distinct urinary progesterone metabolite...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Distinct urinary progesterone metabolite...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Cycle menstruel › Phase lutéale › Distinct urinary progesterone metabolite...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Prégnanediol › Distinct urinary progesterone metabolite...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Gonadotrophines hypophysaires › Hormone lutéinisante › Distinct urinary progesterone metabolite...
questionsmedicales.fr › Glucides › Oses acides › Acides uroniques › Glucuronates › Glucuronides › Distinct urinary progesterone metabolite...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Cycle menstruel › Distinct urinary progesterone metabolite...