Monte Carlo-derived
activity
molecular breast imaging
quantification
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
21
11
2022
received:
06
07
2022
accepted:
22
12
2022
pmc-release:
01
05
2024
medline:
10
5
2023
pubmed:
31
12
2022
entrez:
30
12
2022
Statut:
ppublish
Résumé
Molecular breast imaging (MBI) of This work outlines the development and performance evaluation of a methodology to absolutely quantify tumor A validated Monte Carlo application of a commercial MBI system was used to simulate over 7000 unique acquisitions of spherical and ellipsoidal tumors in breast tissue. Tumor absolute activity was calculated following background, scatter, and attenuation corrections of tumor region of interest counts. The methodology was first optimized using a set of high-uptake spherical tumors, and its accuracy and precision was then assessed in a set of spherical tumors with clinical uptake conditions. Finally, the performance of the activity methodology was evaluated under various bias and uncertainty conditions to better characterize the technique under expected clinical measurement conditions. In a test set of images with clinically relevant contrast and noise conditions, the mean ± standard deviation relative error in total tumor activity was 0.5% ± 6.5% (n = 2363) under ideal measurement conditions. Allowing for variability in tumor and background contours and in estimated tumor depths, the expected accuracy of the methodology in clinical practice was 0.5% ± 11.1% (n = 2363), with minimal loss of accuracy for ellipsoidal tumors. Planar MBI photopeak images acquired with standard-of-care protocols can be used to accurately quantify absolute tumor
Sections du résumé
BACKGROUND
BACKGROUND
Molecular breast imaging (MBI) of
PURPOSE
OBJECTIVE
This work outlines the development and performance evaluation of a methodology to absolutely quantify tumor
METHODS
METHODS
A validated Monte Carlo application of a commercial MBI system was used to simulate over 7000 unique acquisitions of spherical and ellipsoidal tumors in breast tissue. Tumor absolute activity was calculated following background, scatter, and attenuation corrections of tumor region of interest counts. The methodology was first optimized using a set of high-uptake spherical tumors, and its accuracy and precision was then assessed in a set of spherical tumors with clinical uptake conditions. Finally, the performance of the activity methodology was evaluated under various bias and uncertainty conditions to better characterize the technique under expected clinical measurement conditions.
RESULTS
RESULTS
In a test set of images with clinically relevant contrast and noise conditions, the mean ± standard deviation relative error in total tumor activity was 0.5% ± 6.5% (n = 2363) under ideal measurement conditions. Allowing for variability in tumor and background contours and in estimated tumor depths, the expected accuracy of the methodology in clinical practice was 0.5% ± 11.1% (n = 2363), with minimal loss of accuracy for ellipsoidal tumors.
CONCLUSIONS
CONCLUSIONS
Planar MBI photopeak images acquired with standard-of-care protocols can be used to accurately quantify absolute tumor
Identifiants
pubmed: 36583691
doi: 10.1002/mp.16196
pmc: PMC10175170
mid: NIHMS1861682
doi:
Substances chimiques
Technetium Tc 99m Sestamibi
971Z4W1S09
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2985-2997Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
© 2022 American Association of Physicists in Medicine.
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