17β-estradiol suppresses H

Humans Female Sirtuin 3 / genetics Human Umbilical Vein Endothelial Cells Hydrogen Peroxide / pharmacology MicroRNAs / genetics Estradiol / pharmacology Estrogens Autophagy RNA, Long Noncoding / genetics
17β-estradiol Autophagy PVT1 SIRT3 Senescence miR-31

Journal

The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483

Informations de publication

Date de publication:
03 2023
Historique:
received: 06 09 2022
revised: 17 12 2022
accepted: 27 12 2022
pubmed: 31 12 2022
medline: 8 2 2023
entrez: 30 12 2022
Statut: ppublish

Résumé

17β-estradiol (17β-E Reverse-transcription-polymerase chain reaction was employed to measure the expression of plasmacytoma variant translocation 1 (PVT1), microRNAs (miRNAs), and SIRT3, and the dual-luciferase assay was used to determine their interaction. Electron microscopy observes autophagosomes, green fluorescent protein-microtubule-associated protein 1 light chain 3 (GFP-LC3) staining, and immunoblot analysis with antibodies against LC3，beclin-1, and P62 were conducted to measure autophagy. Cellular senescence was determined using immunoblot analysis with anti-phosphorylated retinoblastoma and senescence-associated β-galactosidase staining. Women with higher estrogen levels (during the 10-13th day of the menstrual cycle or premenopausal) exhibit markedly higher serum levels of PVT1 than women with lower estrogen levels (during the menstrual period or postmenopausal). The dual-luciferase assay showed that PVT1 acts as a sponge for miR-31, and miR-31 binds to its target gene, SIRT3. The 17β-E Our findings demonstrated that 17β-E

Identifiants

DOI: 10.1016/j.jsbmb.2022.106244 PMID: 36584773
pubmed: 36584773
pii: S0960-0760(22)00195-9
doi: 10.1016/j.jsbmb.2022.106244
pii:
doi:

Substances chimiques

Sirtuin 3 EC 3.5.1.-
Hydrogen Peroxide BBX060AN9V
MicroRNAs 0
Estradiol 4TI98Z838E
Estrogens 0
RNA, Long Noncoding 0
SIRT3 protein, human EC 3.5.1.-
MIRN31 microRNA, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106244

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declared no conflicts of interest.

Auteurs

Xiuting Xiang (X)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Malaysia.

Yuyan Wang (Y)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Guanshen Huang (G)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Jianming Huang (J)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Mingjian Gao (M)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Meihua Sun (M)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Hao Xia (H)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Rahmawati Pare (R)

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Malaysia.

Jingjun Li (J)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: 13876928800@163.com.

Yunjun Ruan (Y)

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: ryj86@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 17β-estradiol suppresses H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Sirtuine-3 › 17β-estradiol suppresses H
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › 17β-estradiol suppresses H
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › 17β-estradiol suppresses H
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › 17β-estradiol suppresses H
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › 17β-estradiol suppresses H
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › 17β-estradiol suppresses H
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › 17β-estradiol suppresses H
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › 17β-estradiol suppresses H