Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen.
Journal
Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
04
10
2022
revised:
16
12
2022
accepted:
22
12
2022
pmc-release:
01
01
2024
pubmed:
1
1
2023
medline:
1
2
2023
entrez:
31
12
2022
Statut:
ppublish
Résumé
Prophylactic efficacy of two different delivery platforms for vaccination against Mycobacterium avium (M. avium) were tested in this study; a subunit and an RNA-based vaccine. The vaccine antigen, ID91, includes four mycobacterial antigens: Rv3619, Rv2389, Rv3478, and Rv1886. We have shown that ID91+GLA-SE is effective against a clinical NTM isolate, M. avium 2-151 smt. Here, we extend these results and show that a heterologous prime/boost strategy with a repRNA-ID91 (replicon RNA) followed by protein ID91+GLA-SE boost is superior to the subunit protein vaccine given as a homologous prime/boost regimen. The repRNA-ID91/ID91+GLA-SE heterologous regimen elicited a higher polyfunctional CD4
Identifiants
pubmed: 36586154
pii: S1472-9792(22)00139-1
doi: 10.1016/j.tube.2022.102302
pmc: PMC10361416
mid: NIHMS1905021
pii:
doi:
Substances chimiques
Cytokines
0
Vaccines, DNA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102302Subventions
Organisme : NIAID NIH HHS
ID : 75N93021C00029
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-025713
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125160
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142267
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing interests.
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