Non-prophylactic resveratrol-mediated protection of neurite integrity under chronic hypoxia is associated with reduction of Cav1.2 channel expression and calcium overloading.

Animals Neurites Resveratrol / pharmacology Calcium / metabolism Hypoxia / metabolism Neurons / metabolism Calcium Channels, L-Type
Ca(2+) Cav1.2 Chemical hypoxia LSCM Live imaging N2a cells Neurodegeneration ROS

Journal

Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959

Informations de publication

Date de publication:
03 2023
Historique:
received: 03 10 2022
revised: 17 12 2022
accepted: 19 12 2022
pubmed: 2 1 2023
medline: 15 3 2023
entrez: 1 1 2023
Statut: ppublish

Résumé

Cellular hypoxia is a major cause of oxidative stress, culminating in neuronal damage in neurodegenerative diseases. Numerous ex vivo studies have implicated that hypoxia episodes leading to disruption of Ca

Identifiants

DOI: 10.1016/j.neuint.2022.105466 PMID: 36587745
pubmed: 36587745
pii: S0197-0186(22)00191-7
doi: 10.1016/j.neuint.2022.105466
pii:
doi:

Substances chimiques

Resveratrol Q369O8926L
Calcium SY7Q814VUP
Calcium Channels, L-Type 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105466

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Debasmita Saha (D)

Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, India.

Sushma Vishwakarma (S)

Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.

Rishikesh Kumar Gupta (RK)

International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland.

Avnika Pant (A)

Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, India.

Vaibhav Dhyani (V)

Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, India; Optical Science Centre, Faculty of Science Engineering and Technology, Swinburne University of Technology, Melbourne, Australia.

Sarmeela Sharma (S)

Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.

Saptarshi Majumdar (S)

Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, India.

Inderjeet Kaur (I)

Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.

Lopamudra Giri (L)

Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, India. Electronic address: giril@che.iith.ac.in.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Non-prophylactic resveratrol-mediated...
questionsmedicales.fr › Cellules › Neurones › Neurites › Non-prophylactic resveratrol-mediated...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Polyphénols › Resvératrol › Non-prophylactic resveratrol-mediated...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Non-prophylactic resveratrol-mediated...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Non-prophylactic resveratrol-mediated...
questionsmedicales.fr › Cellules › Neurones › Non-prophylactic resveratrol-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › Non-prophylactic resveratrol-mediated...