Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1.

Humans Receptor, Melanocortin, Type 2 / metabolism Melanocortins Glucocorticoids Hydrocortisone Cryoelectron Microscopy Adrenocorticotropic Hormone / metabolism

Journal

Cell research
ISSN: 1748-7838
Titre abrégé: Cell Res
Pays: England
ID NLM: 9425763

Informations de publication

Date de publication:
01 2023
Historique:
received: 30 06 2022
accepted: 08 11 2022
pmc-release: 01 01 2024
pubmed: 2 1 2023
medline: 6 1 2023
entrez: 1 1 2023
Statut: ppublish

Résumé

G protein-coupled receptors (GPCRs) are regulated by various downstream proteins, of which the melanocortin receptor accessory protein 1 (MRAP1) is closely involved in the regulation of melanocortin receptor 2 (MC2R). Assisted by MRAP1, MC2R responds to adrenocorticotropic hormone (ACTH) and stimulates glucocorticoid biogenesis and cortisol secretion. MC2R activation plays an essential role in the hypothalamic-pituitary-adrenal (HPA) axis that regulates stress response, while its dysfunction causes glucocorticoid insufficiency- or cortisol excess-associated disorders. Here, we present a cryo-electron microscopy (cryo-EM) structure of the ACTH-bound MC2R-G

Identifiants

DOI: 10.1038/s41422-022-00751-6 PMID: 36588120 PMC: PMC9810661
pubmed: 36588120
doi: 10.1038/s41422-022-00751-6
pii: 10.1038/s41422-022-00751-6
pmc: PMC9810661
doi:

Substances chimiques

Receptor, Melanocortin, Type 2 0
Melanocortins 0
Glucocorticoids 0
Hydrocortisone WI4X0X7BPJ
Adrenocorticotropic Hormone 9002-60-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-54

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s) under exclusive licence to Center for Excellence in Molecular Cell Science, CAS.

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Auteurs

Ping Luo (P)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Wenbo Feng (W)

Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Shanshan Ma (S)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Antao Dai (A)

The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Kai Wu (K)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Xianyue Chen (X)

Research Center for Deepsea Bioresources, Sanya, Hainan, China.

Qingning Yuan (Q)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Xiaoqing Cai (X)

The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Dehua Yang (D)

The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Research Center for Deepsea Bioresources, Sanya, Hainan, China.
University of Chinese Academy of Sciences, Beijing, China.
ORCID: 0000-0003-3028-3243

Ming-Wei Wang (MW)

Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China. mwwang@simm.ac.cn.
The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. mwwang@simm.ac.cn.
Research Center for Deepsea Bioresources, Sanya, Hainan, China. mwwang@simm.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. mwwang@simm.ac.cn.
ORCID: 0000-0001-6550-9017

H Eric Xu (H)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. eric.xu@simm.ac.cn.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China. eric.xu@simm.ac.cn.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.
ORCID: 0000-0002-6829-8144

Yi Jiang (Y)

School of Life Science and Technology, ShanghaiTech University, Shanghai, China. yjiang@lglab.ac.cn.
Lingang Laboratory, Shanghai, China. yjiang@lglab.ac.cn.
ORCID: 0000-0002-0723-1413

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural basis of signaling regulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 2 › Structural basis of signaling regulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Mélanocortines › Structural basis of signaling regulation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Structural basis of signaling regulation of...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › Structural basis of signaling regulation of...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Structural basis of signaling regulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Mélanocortines › Hormone corticotrope › Structural basis of signaling regulation of...