Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation.
Go/No-go
audition
behavior
lever pressing
licking
medial forebrain bundle
motivation
mouse
perception
perceptual decision-making
reinforcement learning
satiation
Journal
Cell reports methods
ISSN: 2667-2375
Titre abrégé: Cell Rep Methods
Pays: United States
ID NLM: 9918227360606676
Informations de publication
Date de publication:
19 12 2022
19 12 2022
Historique:
received:
06
05
2022
revised:
04
10
2022
accepted:
09
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
Perceptual decision-making tasks are essential to many fields of neuroscience. Current protocols generally reward deprived animals with water. However, balancing animals' deprivation level with their well-being is challenging, and trial number is limited by satiation. Here, we present electrical stimulation of the medial forebrain bundle (MFB) as an alternative that avoids deprivation while yielding stable motivation for thousands of trials. Using licking or lever press as a report, MFB animals learnt auditory discrimination tasks at similar speed to water-deprived mice. Moreover, they more reliably reached higher accuracy in harder tasks, performing up to 4,500 trials per session without loss of motivation. MFB stimulation did not impact the underlying sensory behavior since psychometric parameters and response times are preserved. MFB mice lacked signs of metabolic or behavioral stress compared with water-deprived mice. Overall, MFB stimulation is a highly promising tool for task learning because it enhances task performance while avoiding deprivation.
Identifiants
pubmed: 36590697
doi: 10.1016/j.crmeth.2022.100355
pii: S2667-2375(22)00252-1
pmc: PMC9795331
doi:
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
100355Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
None of the authors have any competing interests to declare.
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