Virus Evolution Faced to Multiple Host Targets: The Potyvirus-Pepper Case Study.
Genetic drift
Polygenic resistance
Quantitative resistance
Recessive resistance
Resistance QTL
Resistance durability
Selection
eIF4E
Journal
Current topics in microbiology and immunology
ISSN: 0070-217X
Titre abrégé: Curr Top Microbiol Immunol
Pays: Germany
ID NLM: 0110513
Informations de publication
Date de publication:
2023
2023
Historique:
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
5
1
2023
Statut:
ppublish
Résumé
The wealth of variability amongst genes controlling immunity against potyviruses in pepper (Capsicum spp.) has been instrumental in understanding plant-virus co-evolution and major determinants of plant resistance durability. Characterization of the eukaryotic initiation factor 4E1 (eIF4E1), involved in mRNA translation, as the basis of potyvirus resistance in pepper initiated a large body of work that showed that recessive resistance to potyviruses and other single-stranded positive-sense RNA viruses resulted from mutations in eukaryotic initiation factors in many plant crop species. Combining mutations in different eIF4Es in the same pepper genotype had complex effects on the breadth of the resistance spectrum and on resistance durability, revealing a trade-off between these two traits. In addition, combining eIF4E1 mutations with a quantitatively resistant genetic background had a strong positive effect on resistance durability. Analysing the evolutionary forces imposed by pepper genotypes onto virus populations allowed identifying three key factors improving plant resistance durability: the complexity of mutational pathways involved in virus adaptation to the plant resistance, the decrease of competitivity induced by these mutations on the virus and the intensity of genetic drift imposed by plant genotypes on the virus during its infection cycle.
Identifiants
pubmed: 36592244
doi: 10.1007/978-3-031-15640-3_3
doi:
Substances chimiques
Eukaryotic Initiation Factor-4E
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121-138Informations de copyright
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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