Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients.

To evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID). Multicentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year. We studied 80 (33 men/47 women) patients (111 affected eyes) with a mean age of 41.6±11.7 years. The IMID included were: spondyloarthritis (n=43), Behçet's disease (n=10), psoriatic arthritis (n=8), Crohn's disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1), CONCLUSIONS: CZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs.

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Competing interests: JLM-V received grants/research support from AbbVie, Pfizer, Lilly, Celgene, Janssen, and UCB Pharma. VC-R received grants/research support from MSD and Roche and had consultation fees/participation in the company-sponsored speaker’s bureau from AbbVie, Lilly, Celgene, Grünenthal and UCB Pharma. LS-B received grants/research support from Roche, Lilly and Pfizer. EB-C had consultation fees/participation in the company-sponsored speaker’s bureau from AbbVie, Amgen, Janssen, MSD, Pfizer, Lilly, Novartis y UCB. PF received grants/research supports from Sobi and Novartis and had consultation fees/participation in the company-sponsored speaker’s bureau from Sobi and Novartis. AGM received consultation fees from Novartis and Amgem and sponsored speaker’s bureau from Novartis, Jansen, Amgen, UCB and Grünenthal. MC-C was a lecturer for AbbVie, Merck Sharp & Dohme, Allergan and UCB. He also participated in Advisory Boards for AbbVie and Allergan. He also had travel grants from AbbVie, UCB and Allergan. RV had consultation fees/participation in the company-sponsored speaker’s bureau from AbbVie, Pfizer, MSD, UCB, Gebro, Celgene, Janssen, Bristol Myers, Lilly, Galápagos, Amgen. CF-C received honoraria for lectures/presentations from AbbVie, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer and UCB; consulting fees from AbbVie, Janssen, Lilly, Novartis and UCB and support for attending meetings from AbbVie, Galapagos, Janssen, Lilly, Novartis, Roche and UCB. JLH received grants/research support from Amgen and participation in company-sponsored speaker’s bureau from Amgen, MSD and Novartis. RB received grants/research support from AbbVie, MSD and Roche, and had consultation fees/participation in a company-sponsored speaker’s bureau from AbbVie, Pfizer, Roche, Bristol Myers, Janssen and MSD.