Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) - a study protocol.
Adult cardiology
Cardiac surgery
Cardiology
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
05 01 2023
05 01 2023
Historique:
entrez:
5
1
2023
pubmed:
6
1
2023
medline:
10
1
2023
Statut:
epublish
Résumé
Prehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impact of prehabilitation in patients undergoing cardiac surgery, despite the fact these patients are generally older and have more comorbidities and frailty. This trial will assess the feasibility and impact of a prehabilitation intervention consisting of exercise and inspiratory muscle training on preoperative functional exercise capacity in adult patients awaiting elective cardiac surgery, and determine any impact on clinical outcomes after surgery. PrEPS is a randomised controlled single-centre trial recruiting 180 participants undergoing elective cardiac surgery. Participants will be randomised in a 1:1 ratio to standard presurgical care or standard care plus a prehabilitation intervention. The primary outcome will be change in functional exercise capacity measured as change in the 6 min walk test distance from baseline. Secondary outcomes will evaluate the impact of prehabilitation on preoperative and postoperative outcomes including; respiratory function, health-related quality of life, anxiety and depression, frailty, and postoperative complications and resource use. This trial will evaluate if a prehabilitation intervention can improve preoperative physical function, inspiratory muscle function, frailty and quality of life prior to surgery in elective patients awaiting cardiac surgery, and impact postoperative outcomes. A favourable opinion was given by the Sheffield Research Ethics Committee in 2019. Trial findings will be disseminated to patients, clinicians, commissioning groups and through peer-reviewed publication. ISRCTN13860094.
Identifiants
pubmed: 36604134
pii: bmjopen-2022-065992
doi: 10.1136/bmjopen-2022-065992
pmc: PMC9827267
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e065992Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Pers Med. 2022 Mar 15;12(3):
pubmed: 35330470
Interact Cardiovasc Thorac Surg. 2019 Oct 1;29(4):608-611
pubmed: 31257409
J Cardiothorac Surg. 2014 Nov 18;9:177
pubmed: 25761494
Prog Cardiovasc Nurs. 2003 Summer;18(3):121-6
pubmed: 12893973
BMJ Open. 2020 Sep 3;10(9):e038001
pubmed: 32883735
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
BMJ Open. 2021 Sep 7;11(9):e049202
pubmed: 34493516
Arch Phys Med Rehabil. 2011 Apr;92(4):611-9
pubmed: 21440707
Clin Rehabil. 2015 May;29(5):426-38
pubmed: 25160007
Int J Environ Res Public Health. 2022 Apr 04;19(7):
pubmed: 35410009
Health Psychol. 2004 Sep;23(5):443-51
pubmed: 15367063
Can J Anaesth. 2021 Apr;68(4):514-529
pubmed: 33442834
Am Heart J. 2021 Sep;239:52-58
pubmed: 33957101
J Thorac Cardiovasc Surg. 2019 Apr;157(4):e199-e200
pubmed: 30901806
Heliyon. 2020 Dec 17;6(12):e05759
pubmed: 33364510
Cochrane Database Syst Rev. 2012 Nov 14;11:CD010118
pubmed: 23152283
Clin Rehabil. 2019 Aug;33(8):1320-1330
pubmed: 30977397
Med J Aust. 2008 Jun 16;188(12):712-4
pubmed: 18558894
Medicine (Baltimore). 2018 Oct;97(42):e12925
pubmed: 30335028
Health Policy. 1996 Jul;37(1):53-72
pubmed: 10158943
JAMA Netw Open. 2018 Oct 5;1(6):e183605
pubmed: 30646252
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Circ J. 2014;78(8):2022-93
pubmed: 25047729
BMJ. 2017 Aug 8;358:j3702
pubmed: 28790033
J Cardiothorac Vasc Anesth. 2019 Aug;33(8):2255-2265
pubmed: 30765210
Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624
pubmed: 12186831
Implement Sci. 2018 Jun 7;13(1):80
pubmed: 29879986
J Physiother. 2014 Jun;60(2):66-77
pubmed: 24952833
Cochrane Database Syst Rev. 2015 Oct 05;(10):CD010356
pubmed: 26436600
Respiration. 2010;80(5):410-8
pubmed: 20699610
J Am Geriatr Soc. 2007 Dec;55(12):1940-7
pubmed: 17979958