Clinical relevance of low bone density in cystic fibrosis adult patients: A pilot study.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
06 Jan 2023
06 Jan 2023
Historique:
entrez:
6
1
2023
pubmed:
7
1
2023
medline:
11
1
2023
Statut:
ppublish
Résumé
Survival improvement in cystic fibrosis (CF) is associated with more frequent long-term complications, including CF related bone disease (CFBD). Impact of CFBD on global health outcome remains poorly described. We aimed to assess the relationship between low bone mineral density (BMD) and spinal pain, disability, and quality of life in CF adult patients. This monocentric cross-sectional study with prospective data collection was conducted from November 2016 to December 2019 in the Department of Respiratory Diseases at the University Hospital of Reims (NCT02924818). BMD was assessed by X-ray absorptiometry (DXA). Disability was assessed by the Health Assessment Questionnaire (HAQ). Quality of life was assessed by both the St George's Respiratory Questionnaire and the Cystic Fibrosis Questionnaire for teenagers and adults (CFQ 14+). Forty patients were analyzed, 68% of men, with a median age of 25 years, a median body mass index of 21 kg/m² and a median FEV1% of 54%. Nine patients (23%) had spinal pain. Ten patients (25%) had a low BMD. Compared with patients with normal BMD, patients with low BMD had a significantly lower BMI (22 vs 19 kg/m²; P = .006) and less vitamin D supplementation (33% vs 0%; P = .035). Low BMD was not associated with spinal pain, disability and quality of life. Low BMD is frequent in CF, affecting 1-quarter of adult patients. No significant association was found between low BMD and spinal pain, disability or quality of life.
Identifiants
pubmed: 36607849
doi: 10.1097/MD.0000000000032227
pii: 00005792-202301060-00004
pmc: PMC9829254
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e32227Informations de copyright
Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
Références
Bell SC, Mall MA, Gutierrez H, et al. The future of cystic fibrosis care: a global perpective. Lancet Respir Med. 2020;8:65–124.
Anabtawi A, Le T, Putman M, et al. Cystic fibrosis bone disease: pathophysiology, assessment and prognostic implications. J Cyst Fibros. 2019;18:S48–55.
Pacou J, Zeboulon N, Combescure C, et al. The prevalence of osteoporosis, osteopenia, and fractures among adults with cystic fibrosis: a systematic literature review with meta-analysis. Calcif Tissue Int. 2010;86:1–7.
Schmoll A, Launois C, Perotin JM, et al. Prevalence and impact of rheumatologic pain in cystic fibrosis adult patients. Front Med (Lausanne). 2022;8:804892.
Putman MS, Anabtawi A, Le T, et al. Cystic fibrosis bone disease treatment: current knowledge and future directions. J Cyst Fibros. 2019;18:S56–65.
Sermet-Gaudelus I, Bianchi ML, Garabedian M, et al. European cystic fibrosis bone mineralisation guidelines. J Cystic Fibros. 2011;10(Suppl. 2):S16–23.
Guillemin F, Brainçon S, Pourel J. Measurement of the functional capacity in rheumatoid polyarthritis: a French adaptation of the Health Assessment Questionnaire (HAQ). Rev Rhum Mal Osteoartic. 1991;58:459–65.
Quittner AL, Buu A, Messer MA, et al. Development and validation of the cystic fibrosis questionnaire in the United States: a health-related quality-of-life measure for cystic fibrosis. Chest. 2005;128:2347–54.
Padilla A, Olveira G, Olveira C, et al. Validity and reliability of the St George’s respiratory questionnaire in adults with cystic fibrosis. Arch Bronchoneumol. 2007;43:205–11.
Elkin SL, Fairney A, Burnett S, et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int. 2001;12:366–72.
Conway SP, Morton AM, Oldroyd B, et al. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax. 2000;55:798–804.
Koch AK, Brömme S, Wollschläger B, et al. Musculoskeletal manifestations and rheumatic symptoms in patients with cystic fibrosis (CF) – no observations of CF-specific arthropathy. J Rheumatol. 2008;35:1882–91.
Rossini M, Del Marco A, Dal Santo F, et al. Prevalence and correlates of vertebral fractures in adults with fibrosis. Bone. 2004;35:771–6.
Stephenson A, Jamal S, Dowdell T, et al. Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density. Chest. 2006;130:539–44.
Aris RM, Renner JB, Winders AD, et al. Increased rate fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med. 1998;128:186–93.
Contreras-Bolivar V, Oliveira C, Ruiz-Garcia I, et al. Handgrip Strength: associations with clinical variables, body composition, and bone mineral density in adults with cystic fibrosis. Nutrients. 2021;13:4107.
Vanacor R, Raimundo FV, Marcondes NA, et al. Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis. Rev Assoc Med Bras. 2014;60:53–8.
Mailhot G, Dion N, Farlay D, et al. Impaired rib bone mass and quality in end-stage cystic fibrosis patients. Bone. 2017;98:9–17.
Spira A, Gutierrez C, Chaparro C, et al. Osteoporosis and lung transplantation: a prospective study. Chest. 2000;117:476–81.
Mathiesen IH, Pressler T, Oturai P, et al. Osteoporosis is associated with deteriorating clinical status in adults with cystic fibrosis. Int J Endocrinol. 2018;26:4803974.
Mediati RD, Vellucci R, Dorado L. Pathogenesis and clinical aspects of pain in patients with osteoporosis. Clin Cases Miner Bone Metab. 2014;11:169–72.
Tattersall R, Walshaw MJ. Posture and cystic fibrosis. J R Soc Med. 2003;96(Suppl 43):18–22.
Habib AR, Manji J, Wilcox PG, et al. A systematic review of factors associated with health-related quality of life in adolescents and adults with cystic fibrosis. Ann Am Thorac Soc. 2015;12:420–8.
Cronly JA, Duff AJ, Riekert KA, et al. Health-related quality of life in adolescents and adults with cystic fibrosis: physical and mental health predictors. Respir Care. 2019;64:406–15.