PGE
HPV6/11
NK cell activation/degranulation
PGE2
PGE2 receptors
Recurrent respiratory papillomatosis
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
12
12
2022
received:
13
06
2022
accepted:
05
01
2023
medline:
12
4
2023
pubmed:
7
1
2023
entrez:
6
1
2023
Statut:
ppublish
Résumé
Recurrent respiratory papillomatosis (RRP), a rare chronic disease caused primarily by human papillomavirus types 6 and 11, consists of repeated growth of premalignant papillomas in the airway. RRP is characterized by multiple abnormalities in innate and adaptive immunity. Natural killer (NK) cells play important roles in immune surveillance and are part of the innate immune responses that help prevent tumor growth. We identified that papillomas lack classical class I MHC and retain nonclassical class I MHC expression. Moreover, in this study, we have identified and characterized the mechanism that blocks NK cell targeting of papilloma cells. Here, we show for the first time that the PGE
Identifiants
pubmed: 36608264
doi: 10.1002/eji.202250036
doi:
Substances chimiques
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2250036Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE017227
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137073
Pays : United States
Informations de copyright
© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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