Secosteroid-quinoline hybrids as new anticancer agents.
Azomethines
Breast cancer
Cytotoxicity
Estrogen receptor α
Hydrazides
Quinolines
Secosteroids
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
17
10
2022
revised:
23
12
2022
accepted:
31
12
2022
pubmed:
8
1
2023
medline:
14
3
2023
entrez:
7
1
2023
Statut:
ppublish
Résumé
An elegant approach to unknown secosteroid-quinoline hybrids is disclosed. A series of 13,17-secoestra-1,3,5(10)-trien-17-oic acid [N'-(iso)quinolylmethylene]hydrazides was prepared and these novel type of secosteroids was screened for antiproliferative activity against estrogen-responsive human breast cancer cell line MCF-7. Most of the synthesized compounds showed a cytotoxic effect superior to that of reference drug cisplatin; the lead compound exhibits the highest activity with the IC
Identifiants
pubmed: 36608906
pii: S0960-0760(22)00196-0
doi: 10.1016/j.jsbmb.2022.106245
pii:
doi:
Substances chimiques
Cisplatin
Q20Q21Q62J
Trientine
SJ76Y07H5F
Antineoplastic Agents
0
Quinolines
0
Secosteroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106245Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.