A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 01 2023
06 01 2023
Historique:
received:
20
12
2021
accepted:
24
11
2022
pubmed:
8
1
2023
medline:
11
1
2023
entrez:
7
1
2023
Statut:
epublish
Résumé
Immune checkpoint therapy in breast cancer remains restricted to triple negative patients, and long-term clinical benefit is rare. The primary aim of immune checkpoint blockade is to prevent or reverse exhausted T cell states, but T cell exhaustion in breast tumors is not well understood. Here, we use single-cell transcriptomics combined with imaging mass cytometry to systematically study immune environments of human breast tumors that either do or do not contain exhausted T cells, with a focus on luminal subtypes. We find that the presence of a PD-1
Identifiants
pubmed: 36609566
doi: 10.1038/s41467-022-35238-w
pii: 10.1038/s41467-022-35238-w
pmc: PMC9822999
doi:
Substances chimiques
Programmed Cell Death 1 Receptor
0
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
98Informations de copyright
© 2023. The Author(s).
Références
Cancer Immunol Res. 2015 Jan;3(1):26-36
pubmed: 25127875
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Cell. 2019 Feb 7;176(4):775-789.e18
pubmed: 30595452
JAMA Oncol. 2019 Aug 01;5(8):1205-1214
pubmed: 30973611
Lancet Oncol. 2018 Jan;19(1):40-50
pubmed: 29233559
Anticancer Res. 2014 Mar;34(3):1355-66
pubmed: 24596383
Nat Methods. 2017 Sep;14(9):873-876
pubmed: 28783155
Mod Pathol. 2019 Jan;32(1):70-80
pubmed: 30154578
Nature. 2020 Feb;578(7796):615-620
pubmed: 31959985
BMC Genomics. 2018 Jun 19;19(1):477
pubmed: 29914354
Bioinformatics. 2019 Jan 1;35(1):28-35
pubmed: 29939207
Nature. 2019 Jul;571(7764):270-274
pubmed: 31207604
Nat Rev Immunol. 2020 Jan;20(1):7-24
pubmed: 31467405
Cancer Cell. 2018 Apr 9;33(4):547-562
pubmed: 29634943
Nat Commun. 2020 Dec 2;11(1):6175
pubmed: 33268821
Front Cell Infect Microbiol. 2020 Feb 13;10:49
pubmed: 32117816
Cell. 2018 Nov 1;175(4):998-1013.e20
pubmed: 30388456
J Clin Pathol. 2016 May;69(5):422-30
pubmed: 26475777
Nat Biotechnol. 2021 Sep;39(9):1103-1114
pubmed: 33349700
Nat Med. 2018 Jul;24(7):986-993
pubmed: 29942092
Gigascience. 2018 Jul 1;7(7):
pubmed: 30010766
Sci Immunol. 2020 Apr 17;5(46):
pubmed: 32303573
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2794-802
pubmed: 23011795
Nat Methods. 2020 Feb;17(2):159-162
pubmed: 31819264
Cell. 2018 Aug 23;174(5):1293-1308.e36
pubmed: 29961579
Nat Methods. 2014 Apr;11(4):417-22
pubmed: 24584193
EBioMedicine. 2019 Sep;47:78-88
pubmed: 31439476
Cell. 2019 Oct 31;179(4):829-845.e20
pubmed: 31675496
Front Immunol. 2017 Dec 19;8:1830
pubmed: 29312327
Nat Methods. 2017 Mar;14(3):309-315
pubmed: 28114287
Sci Immunol. 2022 Apr;7(70):eabk1692
pubmed: 35363540
Nat Methods. 2019 Dec;16(12):1226-1232
pubmed: 31570887
Genome Biol. 2019 Dec 23;20(1):296
pubmed: 31870423
J Clin Invest. 2013 Jul;123(7):2873-92
pubmed: 23778140
Front Immunol. 2021 Feb 25;12:643692
pubmed: 33717201
Cancer Immunol Res. 2019 May;7(5):784-796
pubmed: 30872264
Nat Commun. 2018 Jul 13;9(1):2724
pubmed: 30006565
Nat Immunol. 2014 Apr;15(4):373-83
pubmed: 24584090
Cancer Immunol Immunother. 2021 Mar;70(3):607-617
pubmed: 33015734
J Exp Med. 2003 Jul 21;198(2):305-13
pubmed: 12874263
Breast Care (Basel). 2020 Oct;15(5):450-469
pubmed: 33223989
Cell. 2017 May 4;169(4):736-749.e18
pubmed: 28475899
Int J Oral Sci. 2020 Sep 15;12(1):24
pubmed: 32934197
Cell Res. 2020 Sep;30(9):745-762
pubmed: 32561858
Br J Cancer. 2021 Jan;124(2):359-367
pubmed: 32929195
Cancer Cell. 2011 Apr 12;19(4):541-55
pubmed: 21481794
Nat Med. 2021 May;27(5):820-832
pubmed: 33958794
Nat Commun. 2018 Oct 16;9(1):4297
pubmed: 30327458
Nat Methods. 2020 Feb;17(2):137-145
pubmed: 31792435
Cell Syst. 2018 Jan 24;6(1):25-36.e5
pubmed: 29289569
PLoS Biol. 2018 Jul 3;16(7):e2005970
pubmed: 29969450
Breast Cancer Res Treat. 2013 Jun;139(3):667-76
pubmed: 23756627
Oncoimmunology. 2013 Oct 1;2(10):e26066
pubmed: 24244900
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Science. 2020 Feb 21;367(6480):
pubmed: 32079746
F1000Res. 2016 Aug 31;5:2122
pubmed: 27909575
Int J Mol Sci. 2020 Jul 05;21(13):
pubmed: 32635651
Cancer Immunol Res. 2017 Jul;5(7):516-523
pubmed: 28619968
PLoS Med. 2016 Dec 13;13(12):e1002194
pubmed: 27959923
Bioinformatics. 2017 Apr 15;33(8):1179-1186
pubmed: 28088763
Cell Syst. 2019 Apr 24;8(4):329-337.e4
pubmed: 30954475
Cancer Cell. 2021 Jul 12;39(7):928-944.e6
pubmed: 33961783
Nat Rev Cancer. 2020 Apr;20(4):218-232
pubmed: 32024970
Cell. 2018 Sep 6;174(6):1373-1387.e19
pubmed: 30193111
Cancer Cell. 2021 Dec 13;39(12):1578-1593.e8
pubmed: 34653365
FEBS Lett. 2012 Mar 23;586(6):766-71
pubmed: 22293503
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Curr Opin Immunol. 2018 Apr;51:123-132
pubmed: 29567511
Front Immunol. 2019 Oct 29;10:2534
pubmed: 31736961
Nature. 2018 Dec;564(7735):268-272
pubmed: 30479382
Nature. 2020 Apr;580(7802):257-262
pubmed: 32269339
Cell. 2019 May 16;177(5):1330-1345.e18
pubmed: 30982598
Eur Respir J. 2020 Feb 6;55(2):
pubmed: 32029641
Cancer Epidemiol Biomarkers Prev. 2016 Dec;25(12):1625-1634
pubmed: 27672056
Clin Cancer Res. 2017 Jun 1;23(11):2640-2646
pubmed: 28572258
Eur J Immunol. 1988 Oct;18(10):1643-6
pubmed: 3263925
Crit Rev Oncol Hematol. 2019 May;137:57-83
pubmed: 31014516
BMC Cancer. 2015 Mar 06;15:101
pubmed: 25884667
Sci Rep. 2018 Jan 10;8(1):256
pubmed: 29321503
Genome Biol. 2015 Dec 10;16:278
pubmed: 26653891
Bioinformatics. 2020 Dec 26;:
pubmed: 33367748
Nat Rev Cancer. 2008 Aug;8(8):618-31
pubmed: 18633355
Breast Cancer Res. 2021 Jan 7;23(1):4
pubmed: 33413541
Nat Protoc. 2020 Apr;15(4):1484-1506
pubmed: 32103204
J Clin Pathol. 1977 Aug;30(8):758-62
pubmed: 599189
Nat Cancer. 2020 May;1(5):546-561
pubmed: 32803172
Immunol Rev. 2003 Dec;196:7-24
pubmed: 14617194
Front Immunol. 2018 Aug 15;9:1838
pubmed: 30158927
Cancer Res. 2011 Sep 1;71(17):5678-87
pubmed: 21846823
Nat Rev Immunol. 2019 Jun;19(6):369-382
pubmed: 30718830
Nucleic Acids Res. 2020 Jun 4;48(10):e55
pubmed: 32196115
Cell Syst. 2018 May 23;6(5):612-620.e5
pubmed: 29605184
J Clin Oncol. 2018 Jun 10;36(17):1668-1674
pubmed: 29283791