Peripheral Airway Dysfunction in Obesity and Obese Asthma.
impedance
lung function
methacholine
oscillometry
spirometry
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
15
07
2022
revised:
30
11
2022
accepted:
20
12
2022
medline:
11
4
2023
pubmed:
8
1
2023
entrez:
7
1
2023
Statut:
ppublish
Résumé
The purpose of this study was to investigate physiological phenotypes of asthma in obesity. Do physiological responses during bronchoconstriction distinguish different groups of asthma in people with obesity, and also differentiate from responses simply related to obesity? Cross-sectional study of people with obesity (31 with asthma and 22 without lung disease). Participants underwent methacholine challenge testing with measurement of spirometry and respiratory system impedance by oscillometry. Participants had class III obesity (BMI, 46.7 ± 6.6 kg/m Peripheral airway reactivity detected by oscillometry is common in obese control subjects and obese people with asthma. There is a subgroup of obese asthma characterized by significant peripheral airway dysfunction by oscillometry out of proportion to spirometric airway dysfunction. This peripheral dysfunction represents clinically significant respiratory disease not readily assessed by spirometry.
Sections du résumé
BACKGROUND
The purpose of this study was to investigate physiological phenotypes of asthma in obesity.
RESEARCH QUESTION
Do physiological responses during bronchoconstriction distinguish different groups of asthma in people with obesity, and also differentiate from responses simply related to obesity?
STUDY DESIGN AND METHODS
Cross-sectional study of people with obesity (31 with asthma and 22 without lung disease). Participants underwent methacholine challenge testing with measurement of spirometry and respiratory system impedance by oscillometry.
RESULTS
Participants had class III obesity (BMI, 46.7 ± 6.6 kg/m
INTERPRETATION
Peripheral airway reactivity detected by oscillometry is common in obese control subjects and obese people with asthma. There is a subgroup of obese asthma characterized by significant peripheral airway dysfunction by oscillometry out of proportion to spirometric airway dysfunction. This peripheral dysfunction represents clinically significant respiratory disease not readily assessed by spirometry.
Identifiants
pubmed: 36610669
pii: S0012-3692(23)00005-3
doi: 10.1016/j.chest.2022.12.030
pmc: PMC10107055
pii:
doi:
Substances chimiques
Methacholine Chloride
0W5ETF9M2K
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
753-762Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL133920
Pays : United States
Informations de copyright
Copyright © 2023 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
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