Cytotoxic CD8
CD8
MACE
PAR1
atrial fibrillation
atrial myopathy
protease-activated receptor
t cells
thrombin
thrombo-inflammation
tissue factor
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 12 2022
29 12 2022
Historique:
received:
25
11
2022
revised:
23
12
2022
accepted:
26
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8 A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF ( During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8 In patients with FDAF, the TF-factor Xa-factor IIa-axis contributes to thrombo-inflammation via PAR1 in CD8
Sections du résumé
BACKGROUND
Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8
METHODS
A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF (
RESULTS
During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8
CONCLUSIONS
In patients with FDAF, the TF-factor Xa-factor IIa-axis contributes to thrombo-inflammation via PAR1 in CD8
Identifiants
pubmed: 36611934
pii: cells12010141
doi: 10.3390/cells12010141
pmc: PMC9818535
pii:
doi:
Substances chimiques
Receptor, PAR-1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cardiovasc Res. 2014 Mar 1;101(3):344-51
pubmed: 24385341
Eur Heart J. 2021 Sep 7;42(34):3227-3337
pubmed: 34458905
Int J Mol Sci. 2019 Jun 08;20(11):
pubmed: 31181772
J Thromb Haemost. 2016 Oct;14(10):1908-1916
pubmed: 27513692
J Immunol Res. 2022 May 12;2022:3647817
pubmed: 35600045
J Atr Fibrillation. 2017 Apr 30;9(6):1530
pubmed: 29250287
Cardiovasc Diabetol. 2020 Feb 17;19(1):20
pubmed: 32066445
Circ Heart Fail. 2015 Jul;8(4):776-87
pubmed: 26022677
Int Heart J. 2012;53(4):221-4
pubmed: 22878798
Cells. 2021 Dec 13;10(12):
pubmed: 34944024
Circulation. 2022 Oct 18;146(16):1196-1206
pubmed: 36030390
Res Pract Thromb Haemost. 2020 Dec 06;5(1):17-26
pubmed: 33537526
Immunology. 2011 Sep;134(1):17-32
pubmed: 21711350
J Immunol. 2011 Oct 15;187(8):4061-7
pubmed: 21918190
J Am Heart Assoc. 2018 Feb 1;7(3):
pubmed: 29419389
Biomolecules. 2021 Aug 07;11(8):
pubmed: 34439833
J Clin Invest. 2013 Mar;123(3):1310-22
pubmed: 23391721
Thromb Haemost. 2017 Jan 26;117(2):349-356
pubmed: 27904907
J Infect Dis. 2013 Feb 15;207(4):638-50
pubmed: 23204166
Eur Heart J Acute Cardiovasc Care. 2022 Nov 2;11(10):772-781
pubmed: 35925661
Thromb Haemost. 2020 Apr;120(4):538-564
pubmed: 32289858
Nat Rev Immunol. 2018 Dec;18(12):733-744
pubmed: 30228378
J Immunol. 2013 Mar 1;190(5):2354-61
pubmed: 23365082
Eur J Pharmacol. 2013 Oct 15;718(1-3):114-23
pubmed: 24041930
Eur Heart J. 2019 Oct 21;40(40):3318-3332
pubmed: 31004144
Sci Rep. 2018 Jun 25;8(1):9624
pubmed: 29941960
J Am Coll Cardiol. 2017 Apr 18;69(15):1990-1992
pubmed: 28408030
Cell Mol Immunol. 2015 Jul;12(4):466-73
pubmed: 25152079
JACC Cardiovasc Imaging. 2020 Aug;13(8):1690-1700
pubmed: 32563642
JCI Insight. 2017 May 4;2(9):
pubmed: 28469072
Thromb Res. 2020 Dec;196:87-98
pubmed: 32853981
Front Cardiovasc Med. 2022 Jul 04;9:879984
pubmed: 35859594
iScience. 2021 Oct 30;24(11):103387
pubmed: 34841225
Inflamm Res. 2021 Dec;70(10-12):1011-1014
pubmed: 34536081
JAMA Intern Med. 2014 Jan;174(1):107-14
pubmed: 24190540
Trends Pharmacol Sci. 2017 Aug;38(8):701-716
pubmed: 28558960
Circ J. 2015;79(11):2329-31
pubmed: 26447121
Eur Heart J. 2021 Feb 1;42(5):373-498
pubmed: 32860505
Herzschrittmacherther Elektrophysiol. 2018 Mar;29(1):76-83
pubmed: 29234866
Cardiovasc Res. 2021 Jul 27;117(9):2030-2044
pubmed: 32931586
Int J Cardiol. 2019 Jul 15;287:174-180
pubmed: 30527991
J Am Coll Cardiol. 2013 Nov 5;62(19):1737-45
pubmed: 23871888
Biomed Res Int. 2017;2017:3678017
pubmed: 28713823
Cell Mol Life Sci. 2016 Aug;73(16):3009-33
pubmed: 27038487
Thromb Haemost. 2020 Aug;120(8):1182-1187
pubmed: 32594507
Curr Pharm Des. 2016;22(4):472-84
pubmed: 26696253
J Am Coll Cardiol. 2022 Jul 26;80(4):283-295
pubmed: 35863844
JACC Basic Transl Sci. 2016 Jul 13;1(5):328-339
pubmed: 27642643
Lancet. 2022 Apr 9;399(10333):1383-1390
pubmed: 35385695
Eur Heart J. 2020 Oct 1;41(37):3549-3560
pubmed: 33080003
Cells. 2020 Dec 29;10(1):
pubmed: 33383733
Cells. 2021 Sep 30;10(10):
pubmed: 34685585
Cardiovasc Ther. 2014 Jun;32(3):113-9
pubmed: 24533719
Am Heart J. 2020 Jan;219:117-127
pubmed: 31699295
Cardiovasc Diabetol. 2018 Feb 24;17(1):34
pubmed: 29477147
Europace. 2016 Dec;18(suppl 4):iv156-iv162
pubmed: 28011843
Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):13-24
pubmed: 30580574
Circulation. 2022 Sep 13;146(11):836-847
pubmed: 35968706
Arch Med Sci Atheroscler Dis. 2020 Jul 11;5:e140-e147
pubmed: 32832713
J Arrhythm. 2015 Apr;31(2):78-82
pubmed: 26336536
Mol Cells. 2020 May 31;43(5):438-447
pubmed: 32345003
Trends Cardiovasc Med. 2014 Aug;24(6):249-55
pubmed: 25066486
Front Physiol. 2012 Jul 05;3:236
pubmed: 22783202
Math Biosci Eng. 2021 May 27;18(4):4696-4712
pubmed: 34198460
Cell Immunol. 2014 Mar-Apr;288(1-2):47-52
pubmed: 24637088
Cardiovasc Res. 2022 Jul 27;118(10):2367-2384
pubmed: 34352109
Clin Res Cardiol. 2020 Oct;109(10):1271-1281
pubmed: 32072262
Nat Rev Cardiol. 2022 Sep 15;:
pubmed: 36109633
FEBS J. 2021 Apr;288(8):2697-2726
pubmed: 33742547
Sci Rep. 2020 Feb 3;10(1):1685
pubmed: 32015492
Nat Commun. 2021 Mar 5;12(1):1483
pubmed: 33674611
J Card Fail. 2020 Mar;26(3):270-275
pubmed: 31857197
PLoS One. 2015 Apr 17;10(4):e0124716
pubmed: 25884835
Circulation. 2021 Sep 14;144(11):845-858
pubmed: 34328366
Nat Rev Cardiol. 2015 Apr;12(4):230-43
pubmed: 25622848
Clin Res Cardiol. 2021 Jun;110(6):831-840
pubmed: 33098470
Europace. 2016 Oct;18(10):1455-1490
pubmed: 27402624
Eur Heart J. 2017 Jan 1;38(1):53-61
pubmed: 26612579