The Improvement of Functional State of Brain Mitochondria with Astaxanthin in Rats after Heart Failure.
astaxanthin (AST)
heart failure
mitochondrial permeability transition pore (mPTP)
oxidative stress
rat brain mitochondria (RBM)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Dec 2022
20 Dec 2022
Historique:
received:
14
11
2022
revised:
12
12
2022
accepted:
15
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
The relationship between neurological damage and cardiovascular disease is often observed. This type of damage is both a cause and an effect of cardiovascular disease. Mitochondria are the key organelles of the cell and are primarily subject to oxidative stress. Mitochondrial dysfunctions are involved in the etiology of various diseases. A decrease in the efficiency of the heart muscle can lead to impaired blood flow and decreased oxygen supply to the brain. Astaxanthin (AST), a marine-derived xanthophyll carotenoid, has multiple functions and its effects have been shown in both experimental and clinical studies. We investigated the effects of AST on the functional state of brain mitochondria in rats after heart failure. Isoproterenol (ISO) was used to cause heart failure. In the present study, we found that ISO impaired the functional state of rat brain mitochondria (RBM), while the administration of AST resulted in an improvement in mitochondrial efficiency. The respiratory control index (RCI) in RBM decreased with the use of ISO, while AST administration led to an increase in this parameter. Ca
Identifiants
pubmed: 36613474
pii: ijms24010031
doi: 10.3390/ijms24010031
pmc: PMC9820232
pii:
doi:
Substances chimiques
Mitochondrial Membrane Transport Proteins
0
astaxanthine
8XPW32PR7I
Xanthophylls
0
Isoproterenol
L628TT009W
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : 20-04-00131
Organisme : Russian Foundation for Basic Research
ID : 20-015-00072
Organisme : Russian Academy of Sciences
ID : State assignment to the Institute of Theoretical and Experimental Biophysics, 075-00381-21-00
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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