Quantitative Metabolomics to Explore the Role of Plasma Polyamines in Colorectal Cancer.
agmatine
biomarker
colorectal cancer
inflammatory indexes
polyamine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Dec 2022
21 Dec 2022
Historique:
received:
07
11
2022
revised:
14
12
2022
accepted:
15
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analytical problems still preclude its clinical practice. We exploited ultra-high-resolution liquid chromatography and mass spectrometry, as a highly sensitive and innovative method, to profile eleven polyamines, including spermine and spermidine with their acetylated forms. These data together with an evaluation of the inflammatory indexes might represent suitable biomarkers for the identification of CRC patients. The statistical models revealed good discrimination in distinguishing CRC patients from healthy subjects. The plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, revealed helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, together with the application of an innovative technology, could represent a valuable tool for discriminating patients from different clinical groups.
Identifiants
pubmed: 36613539
pii: ijms24010101
doi: 10.3390/ijms24010101
pmc: PMC9820724
pii:
doi:
Substances chimiques
Polyamines
0
Spermidine
U87FK77H25
Spermine
2FZ7Y3VOQX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Banco di Sardegna, Italy, and "Fondo di Ateneo per la Ricerca 2020" from University of Sassari, Italy
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