A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.
genetic variants
human longevity
protein signatures
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Dec 2022
21 Dec 2022
Historique:
received:
17
11
2022
revised:
08
12
2022
accepted:
15
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls. The analysis identified a locus in CDKN2B-AS1 (rs6475609,
Identifiants
pubmed: 36613555
pii: ijms24010116
doi: 10.3390/ijms24010116
pmc: PMC9820206
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : UH2AG064704
Pays : United States
Organisme : NIH HHS
ID : U19AG063893
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG061844
Pays : United States
Organisme : NIH HHS
ID : U19AG023122
Pays : United States
Organisme : NIA NIH HHS
ID : UH2 AG064704
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG023122
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG038072
Pays : United States
Organisme : NIA NIH HHS
ID : UH3 AG064704
Pays : United States
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