The Role of
Staphylococcus aureus
Staphylococcus aureus enterotoxin B
allergen
allergic asthma
atopic diseases
microbial colonization
serine protease-like protein
staphylococcal protein A
toxic-shock-syndrome toxin 1
toxin-specific IgE-sensitization
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Dec 2022
30 Dec 2022
Historique:
received:
07
11
2022
revised:
15
12
2022
accepted:
20
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
Bronchial asthma is one of the most common chronic diseases worldwide and affects more than 300 million patients. Allergic asthma affects the majority of asthmatic children as well as approximately 50% of adult asthmatics. It is characterized by a Th2-mediated immune response against aeroallergens. Many aspects of the overall pathophysiology are known, while the underlying mechanisms and predisposing factors remain largely elusive today. Over the last decade, respiratory colonization with Staphylococcus aureus (S. aureus), a Gram-positive facultative bacterial pathogen, came into focus as a risk factor for the development of atopic respiratory diseases. More than 30% of the world’s population is constantly colonized with S. aureus in their nasopharynx. This colonization is mostly asymptomatic, but in immunocompromised patients, it can lead to serious complications including pneumonia, sepsis, or even death. S. aureus is known for its ability to produce a wide range of proteins including toxins, serine-protease-like proteins, and protein A. In this review, we provide an overview of the current knowledge about the pathophysiology of allergic asthma and to what extent it can be affected by different toxins produced by S. aureus. Intensifying this knowledge might lead to new preventive strategies for atopic respiratory diseases.
Identifiants
pubmed: 36614093
pii: ijms24010654
doi: 10.3390/ijms24010654
pmc: PMC9820472
pii:
doi:
Substances chimiques
Enterotoxins
0
Allergens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Mitteldeutsche Gesellschaft für Pneumologie und Thoraxchirurgie
ID : 2019-MDGP-PA-001
Organisme : RTG 2408
ID : 361210922
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