Expeditious fluorimetric detection of bilirubin by simple imidazole derived luminophore and it's pragmatic applicability in spiked biological fluids.
Bilirubin
Bio-fluids
FRET
Fluorimetric detection
Imidazole
Journal
Analytica chimica acta
ISSN: 1873-4324
Titre abrégé: Anal Chim Acta
Pays: Netherlands
ID NLM: 0370534
Informations de publication
Date de publication:
25 Jan 2023
25 Jan 2023
Historique:
received:
21
07
2022
revised:
19
11
2022
accepted:
25
11
2022
entrez:
11
1
2023
pubmed:
12
1
2023
medline:
13
1
2023
Statut:
ppublish
Résumé
Bilirubin is an indispensable biomarker for liver diseases. Utilizing organic molecules as sensor platform for effective detection of bilirubin are little. In addition, the reported fluorophores required longer incubation time for detection. Hence, herein we have attempted to design an imidazole derivative 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N,N-diphenylaniline (IMI) from triphenylamine and pyridine units which could detect bilirubin swiftly without any incubation period. IMI manifested an instant quenching of emission in presence of bilirubin with limit of detection (LOD) 11.74 × 10
Identifiants
pubmed: 36628705
pii: S0003-2670(22)01249-1
doi: 10.1016/j.aca.2022.340678
pii:
doi:
Substances chimiques
Bilirubin
RFM9X3LJ49
Imidazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
340678Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.