Mechanisms of sex differentiation and sex reversal in hermaphrodite fish as revealed by the Epinephelus coioides genome.
Epinephelus coioides
chromosome-level genome assembly
sex differentiation
sex reversal
socially controlled sex change
transcriptomics
Journal
Molecular ecology resources
ISSN: 1755-0998
Titre abrégé: Mol Ecol Resour
Pays: England
ID NLM: 101465604
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
13
12
2022
received:
26
02
2022
accepted:
28
12
2022
medline:
6
4
2023
pubmed:
12
1
2023
entrez:
11
1
2023
Statut:
ppublish
Résumé
Most grouper species are functional protogynous hermaphrodites, but the genetic basis and the molecular mechanisms underlying the regulation of this unique reproductive strategy remain enigmatic. In this study, we report a high-quality chromosome-level genome assembly of the representative orange-spotted grouper (Epinephelus coioides). No duplication or deletion of sex differentiation-related genes was found in the genome, suggesting that sex development in this grouper may be related to changes in regulatory sequences or environmental factors. Transcriptomic analyses showed that aromatase and retinoic acid are probably critical to promoting ovarian fate determination, and follicle-stimulating hormone triggers the female-to-male sex change. Socially controlled sex-change studies revealed that, in sex-changing fish, the brain's response to the social environment may be mediated by activation of the phototransduction cascade and the melatonin synthesis pathway. In summary, our genomic and experimental results provide novel insights into the molecular mechanisms of sex differentiation and sex change in the protogynous groupers.
Identifiants
pubmed: 36631404
doi: 10.1111/1755-0998.13753
doi:
Substances chimiques
Fish Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
920-932Subventions
Organisme : Guangdong Provincial Special Fund For Modern Agriculture Industry Technology Innovation Teams
ID : 2019KJ143
Organisme : Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
ID : 311021006
Organisme : Key-Area Research and Development Program of Guangdong Province
ID : 2021B0202020002
Organisme : National Natural Science Foundation of China
ID : 31972769
Organisme : National Natural Science Foundation of China
ID : 31902346
Organisme : National Natural Science Foundation of China
ID : 32172968
Organisme : Natural Science Foundation for Fundamental Research in Shenzhen
ID : JCYJ20190812105801661
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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