γδ T cells are effectors of immunotherapy in cancers with HLA class I defects.

Humans Colonic Neoplasms / drug therapy Histocompatibility Antigens Class I / genetics Immune Checkpoint Inhibitors / pharmacology Immunotherapy Receptors, Antigen, T-Cell, gamma-delta / immunology T-Lymphocytes / immunology beta 2-Microglobulin / deficiency DNA Mismatch Repair / genetics Receptors, KIR Cell Line, Tumor Organoids Antigen Presentation Genes, MHC Class I / genetics

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
01 2023

Historique:

received: 16 07 2021

accepted: 24 11 2022

pubmed: 12 1 2023

medline: 28 1 2023

entrez: 11 1 2023

Statut: ppublish

Résumé

DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune checkpoint blockade (ICB)

Identifiants

DOI: 10.1038/s41586-022-05593-1 PMID: 36631610 PMC: PMC9876799

pubmed: 36631610

doi: 10.1038/s41586-022-05593-1

pii: 10.1038/s41586-022-05593-1

pmc: PMC9876799

doi:

Substances chimiques

Histocompatibility Antigens Class I 0

Immune Checkpoint Inhibitors 0

Receptors, Antigen, T-Cell, gamma-delta 0

beta 2-Microglobulin 0

PDCD1 protein, human 0

Receptors, KIR 0

CTLA4 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

743-750

Commentaires et corrections

Type : CommentIn

Informations de copyright

Références

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