Sex-specifics of ECT outcome.
ECT
Electroconvulsive therapy
Major depressive disorder
Phenotype
Predictor
Sex
Sex-specific
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 04 2023
01 04 2023
Historique:
received:
02
03
2022
revised:
23
12
2022
accepted:
25
12
2022
pubmed:
13
1
2023
medline:
25
2
2023
entrez:
12
1
2023
Statut:
ppublish
Résumé
Electroconvulsive therapy (ECT) is the most effective treatment for patients with severe major depressive disorder (MDD). Given the known sex differences in MDD, improved knowledge may provide more sex-specific recommendations in clinical guidelines and improve outcome. In the present study we examine sex differences in ECT outcome and its predictors. Clinical data from 20 independent sites participating in the Global ECT-MRI Research Collaboration (GEMRIC) were obtained for analysis, totaling 500 patients with MDD (58.6 % women) with a mean age of 54.8 years. Severity of depression before and after ECT was assessed with validated depression scales. Remission was defined as a HAM-D score of 7 points or below after ECT. Variables associated with remission were selected based on literature (i.e. depression severity at baseline, age, duration of index episode, and presence of psychotic symptoms). Remission rates of ECT were independent of sex, 48.0 % in women and 45.7 % in men (X The evidence provided by our study suggests that ECT as a biological treatment for MDD is equally effective in women and men. A shorter duration of index episode was an additional sex- specific predictor for remission in women. Future research should establish whether the confidence intervals for the corresponding predictive margins are overlapping, as we find, or not.
Identifiants
pubmed: 36632848
pii: S0165-0327(22)01507-5
doi: 10.1016/j.jad.2022.12.144
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-248Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Conflict of interest R.R. received funding from Innovative Medical Research [RE111722 to RR] and German Research Foundation (DFG, grant RE4458/1-1 to RR). U.D. received funding from German Research Foundation #8 FOR2107 DA1151/5-1 and DA1151/5-2 to UD. L.O. received funding from Western Norway Regional Health Authority Grant Nos. 911986 and 912238. A.K. Aki is supported by the Japan Agency for Medical Research and Development (AMED) under Grant Number JP21dm0307102h0003. L.E. received the Research Foundation Flanders (FWO) grant G0C0319N, KU Leuven Research Fund C24/18/095 and the Sequoia Fund for Research on Ageing and Mental Health. P.P. received MH125126 and MH111826. M.K. received a lecture fee by Innomed Medizintechnik in 2017 & 2018 GW received funding from the Brain Foundation of the Netherlands (Hersenstichting). There are no further conflicts of interest.