Derivation of the multiply-branched ergot alkaloid pathway of fungi.
Journal
Microbial biotechnology
ISSN: 1751-7915
Titre abrégé: Microb Biotechnol
Pays: United States
ID NLM: 101316335
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
16
12
2022
received:
26
07
2022
accepted:
02
01
2023
pubmed:
14
1
2023
medline:
25
3
2023
entrez:
13
1
2023
Statut:
ppublish
Résumé
Ergot alkaloids are a large family of fungal specialized metabolites that are important as toxins in agriculture and as the foundation of powerful pharmaceuticals. Fungi from several lineages and diverse ecological niches produce ergot alkaloids from at least one of several branches of the ergot alkaloid pathway. The biochemical and genetic bases for the different branches have been established and are summarized briefly herein. Several pathway branches overlap among fungal lineages and ecological niches, indicating activities of ergot alkaloids benefit fungi in different environments and conditions. Understanding the functions of the multiple genes in each branch of the pathway allows researchers to parse the abundant genomic sequence data available in public databases in order to assess the ergot alkaloid biosynthesis capacity of previously unexplored fungi. Moreover, the characterization of the genes involved in the various branches provides opportunities and resources for the biotechnological manipulation of ergot alkaloids for experimentation and pharmaceutical development.
Identifiants
pubmed: 36636806
doi: 10.1111/1751-7915.14214
pmc: PMC10034635
doi:
Substances chimiques
Ergot Alkaloids
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-756Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM114774
Pays : United States
Informations de copyright
© 2023 The Author. Microbial Biotechnology published by Applied Microbiology International and John Wiley & Sons Ltd.
Références
Sci Rep. 2015 Nov 16;5:16541
pubmed: 26567970
Expert Opin Pharmacother. 2010 Dec;11(18):3085-93
pubmed: 21080856
Commun Biol. 2021 Dec 6;4(1):1362
pubmed: 34873267
BMC Res Notes. 2022 May 18;15(1):183
pubmed: 35585609
Toxins (Basel). 2015 Jan 20;7(1):201-18
pubmed: 25609183
Toxins (Basel). 2015 Jul 27;7(8):2801-21
pubmed: 26226000
Appl Environ Microbiol. 2021 Nov 24;87(24):e0180121
pubmed: 34586904
Mycologia. 2015 Jul-Aug;107(4):667-78
pubmed: 25977213
Curr Biol. 2015 Oct 5;25(19):2562-9
pubmed: 26412136
J Agric Food Chem. 2015 Jan 14;63(1):61-7
pubmed: 25491167
Phytochemistry. 2005 Jun;66(11):1312-20
pubmed: 15904941
Appl Environ Microbiol. 2021 Aug 11;87(17):e0074821
pubmed: 34160271
Chem Biol. 2003 Dec;10(12):1281-92
pubmed: 14700635
Appl Environ Microbiol. 2020 Sep 17;86(19):
pubmed: 32769181
Appl Environ Microbiol. 2020 Jul 2;86(14):
pubmed: 32385081
Appl Environ Microbiol. 1980 Sep;40(3):685-7
pubmed: 7425621
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5681-6
pubmed: 22451903
Toxins (Basel). 2013 Jun 06;5(6):1064-88
pubmed: 23744053
Mol Gen Genet. 1999 Feb;261(1):133-41
pubmed: 10071219
Metab Eng. 2022 Jan;69:198-208
pubmed: 34902590
J Med Chem. 2003 Nov 20;46(24):5117-20
pubmed: 14613313
Toxins (Basel). 2014 Dec 10;6(12):3281-95
pubmed: 25513893
Life Sci. 2011 Aug 15;89(7-8):235-40
pubmed: 21762706
Phytopathology. 2017 May;107(5):504-518
pubmed: 28168931
Int Immunopharmacol. 2005 Sep;5(10):1543-53
pubmed: 16023606
Planta Med. 2018 Jul;84(11):751-758
pubmed: 29499587
Chembiochem. 2006 Jan;7(1):158-64
pubmed: 16397874
CNS Drugs. 2010 Nov;24(11):941-68
pubmed: 20932066
Toxins (Basel). 2013 Feb 22;5(2):445-55
pubmed: 23435153
Nat Prod Rep. 2017 Apr 5;34(4):411-432
pubmed: 28300233
J Struct Biol. 2014 Sep;187(3):207-214
pubmed: 25108240
Alkaloids Chem Biol. 2021;85:1-112
pubmed: 33663751
J Agric Food Chem. 1976 Jul-Aug;24(4):865-8
pubmed: 956545
Chembiochem. 2006 Apr;7(4):645-52
pubmed: 16538694
J Biol Chem. 1998 Dec 4;273(49):32763-70
pubmed: 9830020
Appl Environ Microbiol. 2014 Oct;80(20):6465-72
pubmed: 25107976
Curr Genet. 2016 Nov;62(4):853-860
pubmed: 26972831
Tetrahedron. 1969 Dec;25(24):5879-87
pubmed: 5373534
Nat Prod Rep. 2011 Mar;28(3):496-510
pubmed: 21186384
Microb Cell Fact. 2014 Aug 12;13:95
pubmed: 25112180
Chem Biol. 2014 Jan 16;21(1):146-55
pubmed: 24361048
Appl Environ Microbiol. 2018 Sep 17;84(19):
pubmed: 30076193
Chem Biol. 1997 Mar;4(3):223-30
pubmed: 9115414
J Am Chem Soc. 2010 Feb 17;132(6):1776-7
pubmed: 20102147
Nature. 2005 Dec 22;438(7071):1151-6
pubmed: 16372009
Chem Commun (Camb). 2016 Dec 6;52(99):14306-14309
pubmed: 27885368
PLoS Genet. 2013;9(2):e1003323
pubmed: 23468653
Mycologia. 2007 Nov-Dec;99(6):804-11
pubmed: 18333504
Alkaloids Chem Biol. 2006;63:45-86
pubmed: 17133714
Planta Med. 2006 Apr;72(5):387-92
pubmed: 16557450
J Biol Chem. 2009 Mar 13;284(11):6650-60
pubmed: 19139103
Appl Environ Microbiol. 2010 Jun;76(12):3898-903
pubmed: 20435769
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16796-801
pubmed: 25368161
Am J Pharm Educ. 2006 Oct 15;70(5):98
pubmed: 17149427
Appl Microbiol Biotechnol. 2022 Apr;106(8):2981-2991
pubmed: 35389067
Clin Drug Investig. 2008;28(9):533-52
pubmed: 18666801
Chembiochem. 2009 Sep 21;10(14):2325-8
pubmed: 19672909
Acta Pharm Suec. 1965 Jun;2:231-8
pubmed: 14326398
Angew Chem Weinheim Bergstr Ger. 2015 Apr 20;127(17):5206-5210
pubmed: 27546918
Nat Commun. 2022 Feb 7;13(1):712
pubmed: 35132076
J Agric Food Chem. 2017 Dec 13;65(49):10703-10710
pubmed: 29172518
Sci Rep. 2017 Aug 21;7(1):8930
pubmed: 28827626
Folia Microbiol (Praha). 1973;18(5):390-2
pubmed: 4757982
J Food Prot. 1981 Sep;44(9):702-710
pubmed: 30856725
Microb Biotechnol. 2023 Apr;16(4):742-756
pubmed: 36636806
PLoS Genet. 2011 Jan 06;7(1):e1001264
pubmed: 21253567
Mycologia. 2012 Jul-Aug;104(4):804-12
pubmed: 22453123
Genes (Basel). 2017 Nov 24;8(12):
pubmed: 29186777
Appl Environ Microbiol. 2017 Jun 30;83(14):
pubmed: 28476772
J Biol Chem. 1996 Nov 1;271(44):27524-30
pubmed: 8910337
J Chem Ecol. 2013 Jul;39(7):919-30
pubmed: 23835852
J Am Chem Soc. 1974 Mar 20;96(6):1898-909
pubmed: 4815760
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10733-8
pubmed: 10995477
Mol Plant Pathol. 2009 Jul;10(4):563-77
pubmed: 19523108
Angew Chem Int Ed Engl. 2015 Mar 2;54(10):3004-7
pubmed: 25571861
J Am Chem Soc. 2010 Sep 22;132(37):12835-7
pubmed: 20735127
J Agric Food Chem. 2003 Oct 22;51(22):6429-37
pubmed: 14558758