Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function.

Humans Neurodegenerative Diseases / epidemiology Frontotemporal Dementia / epidemiology Amyotrophic Lateral Sclerosis Alzheimer Disease / epidemiology Cardiovascular Diseases
Alzheimer's disease aging aging and memory cohort study geriatric psychiatry

Journal

Canadian journal of psychiatry. Revue canadienne de psychiatrie
ISSN: 1497-0015
Titre abrégé: Can J Psychiatry
Pays: United States
ID NLM: 7904187

Informations de publication

Date de publication:
05 2023
Historique:
medline: 18 5 2023
pubmed: 14 1 2023
entrez: 13 1 2023
Statut: ppublish

Résumé

Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function. We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD ( Frequency of NPS varied across cohorts (χ NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.

Identifiants

DOI: 10.1177/07067437221147443 PMID: 36637224 PMC: PMC10192827
pubmed: 36637224
doi: 10.1177/07067437221147443
pmc: PMC10192827
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

347-358

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Auteurs

Daniel Kapustin (D)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
ORCID: 0000-0001-5440-2257

Shadi Zarei (S)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Wei Wang (W)

Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
ORCID: 0000-0002-0336-506X

Malcolm A Binns (MA)

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Rotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.

Paula M McLaughlin (PM)

Nova Scotia Health, Halifax, Nova Scotia, Canada.

Agessandro Abrahao (A)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.

Sandra E Black (SE)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

Michael Borrie (M)

University of Western Ontario, London, ON, Canada.

David Breen (D)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Leanna Casaubon (L)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.

Dar Dowlatshahi (D)

Department of Medicine (Neurology), University of Ottawa Brain and Mind Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Elizabeth Finger (E)

University of Western Ontario, London, ON, Canada.

Corinne E Fischer (CE)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Keenan Research Centre for Biomedical Science, St. Michaels Hospital, Toronto, Ontario, Canada.

Andrew Frank (A)

University of Ottawa, Ottawa, ON, Canada.
Bruyere Research Institute, Ottawa, ON, Canada.

Morris Freedman (M)

Rotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.

David Grimes (D)

Department of Medicine (Neurology), University of Ottawa Brain and Mind Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Ayman Hassan (A)

Thunder Bay Regional Research Institute, Northern Ontario School of Medicine, ON, Canada.

Mandar Jog (M)

University of Western Ontario, London, ON, Canada.

Donna Kwan (D)

Queen's University, Kingston, ON, Canada.

Anthony Lang (A)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
Edmond J. Safra Program in Parkinson's Disesase and the Morton and Gloria Shulman Movement Disorders Centre, University Health Network, Toronto, ON, Canada.

Brian Levine (B)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.

Jennifer Mandzia (J)

University of Western Ontario, London, ON, Canada.

Connie Marras (C)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
Edmond J. Safra Program in Parkinson's Disesase and the Morton and Gloria Shulman Movement Disorders Centre, University Health Network, Toronto, ON, Canada.

Mario Masellis (M)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.

Joseph B Orange (JB)

Canadian Centre for Activity and Aging, Western University, ON, Canada.

Stephen Pasternak (S)

University of Western Ontario, London, ON, Canada.
Robarts Research Institute and the Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada.

Alicia Peltsch (A)

Queen's University, Kingston, ON, Canada.

Bruce G Pollock (BG)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Tarek K Rajji (TK)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada.

Angela Roberts (A)

School of Communication, Northwestern University, Evanston, Illinois, USA.
School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.

Demetrios Sahlas (D)

McMaster University, Hamilton, ON, Canada.

Gustavo Saposnik (G)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.

Dallas Seitz (D)

Department of Psychiatry and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Christen Shoesmith (C)

Division of Neurology, Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada.

Alisia Southwell (A)

Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Thomas D L Steeves (TDL)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
University of Ottawa, Ottawa, ON, Canada.

Kelly Sunderland (K)

Rotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.

Richard H Swartz (RH)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Brian Tan (B)

Rotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.

David F Tang-Wai (DF)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
Krembil Brain Institute, Toronto Western Hospital, Toronto, ON, Canada.
Toronto Western Hospital, University Health Network Memory Clinic, Toronto, ON, Canada.

Maria Carmela Tartaglia (MC)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.

Angela Troyer (A)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Neuropsychology and Cognitive Health Program, Baycrest Health Sciences, Toronto, ON, Canada.

John Turnbull (J)

McMaster University, Hamilton, ON, Canada.

Lorne Zinman (L)

Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.

Sanjeev Kumar (S)

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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