Effective dose of ephedrine for treatment of hypotension after induction of general anaesthesia in neonates and infants less than 6 months of age: a multicentre randomised, controlled, open label, dose escalation trial.
arterial pressure
ephedrine
general anaesthesia
hypotension
induction
paediatric anaesthesia
sevoflurane
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
19
07
2022
revised:
18
11
2022
accepted:
10
12
2022
medline:
14
4
2023
pubmed:
14
1
2023
entrez:
13
1
2023
Statut:
ppublish
Résumé
The recommended dose of ephedrine in adults (0.1 mg kg We conducted a multicentre, prospective, randomised, open-label, controlled, dose-escalation trial. Subjects were randomised if presenting a >20% change from baseline in MAP. Six cohorts of 20 subjects each were enrolled. Ten subjects in the first cohort received 0.1 mg kg A total of 119 infants (25% females), with a mean age (standard deviation) of 2.7 (1.3) months, received their allocated dose of ephedrine. The optimal dose of ephedrine was 1.2 mg kg Doses of ephedrine much higher (∼10-fold) than those used in adults are necessary in neonates and infants for the treatment of hypotension after induction of general anaesthesia with sevoflurane. NCT02384876.
Sections du résumé
BACKGROUND
The recommended dose of ephedrine in adults (0.1 mg kg
METHODS
We conducted a multicentre, prospective, randomised, open-label, controlled, dose-escalation trial. Subjects were randomised if presenting a >20% change from baseline in MAP. Six cohorts of 20 subjects each were enrolled. Ten subjects in the first cohort received 0.1 mg kg
RESULTS
A total of 119 infants (25% females), with a mean age (standard deviation) of 2.7 (1.3) months, received their allocated dose of ephedrine. The optimal dose of ephedrine was 1.2 mg kg
CONCLUSIONS
Doses of ephedrine much higher (∼10-fold) than those used in adults are necessary in neonates and infants for the treatment of hypotension after induction of general anaesthesia with sevoflurane.
CLINICAL TRIAL REGISTRATION
NCT02384876.
Identifiants
pubmed: 36639328
pii: S0007-0912(22)00693-6
doi: 10.1016/j.bja.2022.12.006
pii:
doi:
Substances chimiques
Ephedrine
GN83C131XS
Vasoconstrictor Agents
0
Sevoflurane
38LVP0K73A
Banques de données
ClinicalTrials.gov
['NCT02384876']
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
603-610Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.