Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine.
Aggression
Anterior cingulate cortex
Callousness
Childhood trauma
DASB
Fluoxetine
Intermittent explosive disorder
Positron emission tomography
Serotonin transporter
Ventral striatum
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
18
10
2021
accepted:
27
12
2022
pubmed:
15
1
2023
medline:
31
1
2023
entrez:
14
1
2023
Statut:
ppublish
Résumé
Characterizing the neuroanatomical basis of serotonergic abnormalities in severe, chronic, impulsive aggression will allow for rational treatment selection, development of novel therapeutics, and biomarkers to identify at-risk individuals. The aim of this study is to identify associations between regional serotonin transporter (5-HTT) availability and trait and state aggression, as well as response to the anti-aggressive effects of fluoxetine. We examined 5-HTT availability using positron emission tomography (PET) imaging with [ In IED patients, trait aggression was positively associated with [ Consistent with prior reports, ACC 5-HTT is related to trait aggression, and adjusting for factors related to proactive (callousness) and reactive (childhood trauma) aggression subtypes further resolves this relationship. Novel findings of the study include a better understanding of the association between regional 5-HTT availability and state aggression, and the involvement of VST 5-HTT with trait aggression, and with the anti-aggressive effects of fluoxetine.
Identifiants
pubmed: 36640190
doi: 10.1007/s00213-022-06306-2
pii: 10.1007/s00213-022-06306-2
doi:
Substances chimiques
Fluoxetine
01K63SUP8D
Serotonin Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
361-371Subventions
Organisme : NIMH NIH HHS
ID : MH63875
Pays : United States
Organisme : NCRR NIH HHS
ID : MO1-RR-00071
Pays : United States
Organisme : NIMH NIH HHS
ID : MH63875
Pays : United States
Organisme : NCRR NIH HHS
ID : MO1-RR-00071
Pays : United States
Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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