LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus.

Animals Dogs Distemper Virus, Canine / genetics Nectins / genetics Low Density Lipoprotein Receptor-Related Protein-6 Ferrets Receptors, Virus / genetics Cell Adhesion Molecules / genetics Distemper / prevention & control
CRISPR/Cas9 KO screen LRP6 attenuated CDV cell entry receptor

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
28 02 2023
Historique:
pubmed: 17 1 2023
medline: 3 3 2023
entrez: 16 1 2023
Statut: ppublish

Résumé

Wild-type canine distemper virus (CDV) is an important pathogen of dogs as well as wildlife that can infect immune and epithelial cells through two known receptors: the signaling lymphocytic activation molecule (SLAM) and nectin-4, respectively. Conversely, the ferret and egg-adapted CDV-Onderstepoort strain (CDV-OP) is employed as an effective vaccine for dogs. CDV-OP also exhibits promising oncolytic properties, such as its abilities to infect and kill multiple cancer cells

Identifiants

DOI: 10.1128/mbio.03114-22 PMID: 36645301 PMC: PMC9973313
pubmed: 36645301
doi: 10.1128/mbio.03114-22
pmc: PMC9973313
doi:

Substances chimiques

Nectins 0
Low Density Lipoprotein Receptor-Related Protein-6 0
Receptors, Virus 0
Cell Adhesion Molecules 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0311422

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Auteurs

Vaiva Gradauskaite (V)

Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

Marine Inglebert (M)

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

John Doench (J)

Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Melanie Scherer (M)

Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

Martina Dettwiler (M)

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Marianne Wyss (M)

Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Neeta Shrestha (N)

Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Sven Rottenberg (S)

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Bern Center for Precision Medicine, University of Bern, Bern, Switzerland.

Philippe Plattet (P)

Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
ORCID: 0000-0003-3313-2598

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Morbillivirus › Virus de la maladie de Carré › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Nectines › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs Wnt › Protéine-6 apparentée au récepteur des LDL › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Mustelidae › Furets › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › LRP6 Is a Functional Receptor for Attenuated...
questionsmedicales.fr › Maladies de l'animal › Maladies des chiens › Maladie de Carré › LRP6 Is a Functional Receptor for Attenuated...