Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study.
Ageing
Cognition
Cognitive development
Idiopathic normal pressure hydrocephalus
Life-span
Neuropsychology
Older adults
Population-based
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
16 01 2023
16 01 2023
Historique:
received:
22
11
2022
accepted:
11
01
2023
entrez:
16
1
2023
pubmed:
17
1
2023
medline:
19
1
2023
Statut:
epublish
Résumé
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce. To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material. A sample of 104 participants (median [IQR] 75 [72-80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p < 0.05 were used. Median (IQR) time to follow-up was 25 (23-26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045). Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH.
Sections du résumé
BACKGROUND
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce.
AIM
To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material.
METHOD
A sample of 104 participants (median [IQR] 75 [72-80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p < 0.05 were used.
RESULTS
Median (IQR) time to follow-up was 25 (23-26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045).
CONCLUSION
Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH.
Identifiants
pubmed: 36647004
doi: 10.1186/s12877-023-03747-y
pii: 10.1186/s12877-023-03747-y
pmc: PMC9843855
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
29Informations de copyright
© 2023. The Author(s).
Références
Sci Rep. 2020 Oct 23;10(1):18203
pubmed: 33097796
Acta Neurol Belg. 1976 Mar-Apr;76(2):74-82
pubmed: 961374
Clin Neurol Neurosurg. 2016 Apr;143:34-8
pubmed: 26895207
PLoS One. 2020 Apr 24;15(4):e0232275
pubmed: 32330190
J Int Neuropsychol Soc. 2020 Oct;26(9):883-893
pubmed: 32430087
Cogn Affect Behav Neurosci. 2001 Jun;1(2):137-60
pubmed: 12467110
Funct Neurol. 2015 Oct-Dec;30(4):217-28
pubmed: 26727700
PLoS One. 2019 May 29;14(5):e0217705
pubmed: 31141553
J Magn Reson Imaging. 2014 Jun;39(6):1533-42
pubmed: 24006249
J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):723-32
pubmed: 10567486
Cortex. 2017 Jan;86:186-204
pubmed: 27251123
J Neurol Sci. 1965 Jul-Aug;2(4):307-27
pubmed: 5889177
Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):202-11
pubmed: 22163245
Mov Disord Clin Pract. 2021 Aug 05;8(7):1150-1152
pubmed: 34631957
Clin Neurol Neurosurg. 2012 Feb;114(2):130-4
pubmed: 22023722
J Neurol Neurosurg Psychiatry. 2019 Oct;90(10):1117-1123
pubmed: 31167811
Fluids Barriers CNS. 2018 Feb 09;15(1):5
pubmed: 29422104
eNeurologicalSci. 2017 Apr 11;7:27-31
pubmed: 29302622
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Science. 1991 Sep 20;253(5026):1380-6
pubmed: 1896849
Int Urol Nephrol. 2016 Feb;48(2):169-74
pubmed: 26578001
Acta Neurochir (Wien). 2021 Dec;163(12):3373-3386
pubmed: 34480204
J Neurol Sci. 2018 Aug 15;391:54-60
pubmed: 30103972
Psychogeriatrics. 2019 Nov;19(6):557-565
pubmed: 30950145
Dement Geriatr Cogn Disord. 2006;21(2):113-9
pubmed: 16374006
Neuroepidemiology. 2009;32(3):171-5
pubmed: 19096225
Neurosurgery. 2008 Sep;63(3):527-35; discussion 535-6
pubmed: 18812964
J Neurol Neurosurg Psychiatry. 2000 Jun;68(6):778-81
pubmed: 10811706
J Neurol. 2017 Oct;264(10):2141-2148
pubmed: 28879446
Neurosci Bull. 2022 Sep;38(9):1085-1096
pubmed: 35569106
J Neurosurg. 2014 Oct;121(4):776-84
pubmed: 25036194
Cogn Psychol. 2000 Aug;41(1):49-100
pubmed: 10945922
Eur J Nucl Med. 1994 Feb;21(2):118-23
pubmed: 8162934
Acta Neurol Scand. 2007 Nov;116(5):328-32
pubmed: 17922726
J Neurol Neurosurg Psychiatry. 2014 Jul;85(7):806-10
pubmed: 24292998
Front Aging Neurosci. 2022 Feb 23;14:797803
pubmed: 35283746
Eur J Neurol. 2018 Mar;25(3):569-576
pubmed: 29281156
Neurol Med Chir (Tokyo). 2012;52(11):775-809
pubmed: 23183074
J Neurosurg. 2014 Jan;120(1):178-84
pubmed: 24074491
Fluids Barriers CNS. 2021 Aug 14;18(1):37
pubmed: 34391462
Front Aging Neurosci. 2022 May 30;14:904194
pubmed: 35707704
Clin Neurol Neurosurg. 2009 Nov;111(9):752-7
pubmed: 19720451
Acta Neurol Scand. 2020 Mar;141(3):219-225
pubmed: 31778218
Acta Neurochir (Wien). 2022 Feb;164(2):469-478
pubmed: 34970701
Acta Neurol Scand. 2022 Nov;146(5):680-689
pubmed: 36114711
J Neurosurg. 2019 Feb 08;132(3):733-740
pubmed: 30738407
Trends Cogn Sci. 2004 Dec;8(12):539-46
pubmed: 15556023
Acta Neurol Scand. 2012 Oct;126(4):229-37
pubmed: 22587624
Stroke. 1988 May;19(5):604-7
pubmed: 3363593
Neurosurgery. 2005 Sep;57(3 Suppl):S4-16; discussion ii-v
pubmed: 16160425
Acta Neurochir (Wien). 2018 Mar;160(3):509-518
pubmed: 29150794
J Exp Psychol Gen. 2012 Feb;141(1):2-18
pubmed: 21823805
J Neurol. 2020 Sep;267(9):2556-2566
pubmed: 32372182
J Neurol. 1979;222(2):109-18
pubmed: 93629
J Alzheimers Dis. 2021;83(4):1717-1728
pubmed: 34459399
Neurosurgery. 2007 Dec;61(6):1219-26; discussion 1227-8
pubmed: 18162901
Neurol Med Chir (Tokyo). 2021 Feb 15;61(2):63-97
pubmed: 33455998
Acta Neurochir (Wien). 2021 Oct;163(10):2675-2683
pubmed: 34235588
J Neurol Sci. 2009 Feb 15;277(1-2):54-7
pubmed: 18990411
J Cereb Blood Flow Metab. 2004 Jan;24(1):17-23
pubmed: 14688613
Neuropsychopharmacology. 2022 Jan;47(1):72-89
pubmed: 34408280
J Mot Behav. 2021;53(3):373-384
pubmed: 32631206
Funct Neurol. 2016 Jul-Sep;31(3):143-7
pubmed: 27678207