Cortical connectomic mediations on gamma band synchronization in schizophrenia.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
12
08
2019
accepted:
22
12
2022
revised:
07
12
2022
entrez:
18
1
2023
pubmed:
19
1
2023
medline:
21
1
2023
Statut:
epublish
Résumé
Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in patients and controls separately and in the combined sample. The mediation analysis further confirmed that the deficit of gamma band ASSR in schizophrenia was nearly fully mediated by three of the rsFC circuits between right superior temporal gyrus-left medial prefrontal cortex (MPFC), left MPFC-left postcentral gyrus (PoG), and left precentral gyrus-right PoG. Gamma-band ASSR deficits in schizophrenia may be associated with deficient circuitry level connectivity to support gamma frequency synchronization. Correcting gamma band deficits in schizophrenia may require corrective interventions to normalize these aberrant networks.
Identifiants
pubmed: 36653335
doi: 10.1038/s41398-022-02300-6
pii: 10.1038/s41398-022-02300-6
pmc: PMC9849210
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13Subventions
Organisme : NIDA NIH HHS
ID : UH3 DA047685
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014085
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116948
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH123163
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH103222
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB015611
Pays : United States
Organisme : NIH HHS
ID : S10 OD023696
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Behav Res Methods. 2008 Aug;40(3):879-91
pubmed: 18697684
Cereb Cortex. 2005 Dec;15(12):2029-39
pubmed: 15772375
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12699-704
pubmed: 9356513
Int J Psychophysiol. 2011 Jan;79(1):55-63
pubmed: 20713096
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Neuron. 2005 Apr 21;46(2):333-46
pubmed: 15848810
Schizophr Res. 2015 Jun;165(1):97-102
pubmed: 25868936
Biol Psychiatry. 2012 May 15;71(10):873-80
pubmed: 22361076
Clin Neurophysiol. 2001 Sep;112(9):1650-9
pubmed: 11514248
Schizophr Res. 2004 Oct 1;70(2-3):293-302
pubmed: 15329305
Schizophr Res. 2011 Dec;133(1-3):99-105
pubmed: 21849245
Exp Brain Res. 2001 Aug;139(4):377-90
pubmed: 11534861
Nat Neurosci. 1999 Dec;2(12):1131-6
pubmed: 10570492
Neuroimage. 2014 Oct 1;99:571-88
pubmed: 24954281
Brain. 2018 Aug 1;141(8):2511-2526
pubmed: 30020423
Schizophr Res. 2005 May 1;74(2-3):135-47
pubmed: 15721994
Nat Neurosci. 2012 Mar 18;15(4):511-7
pubmed: 22426255
J Neurosci Methods. 2007 Sep 30;165(2):297-305
pubmed: 17624443
Clin Neurophysiol. 2004 Mar;115(3):523-33
pubmed: 15036047
Eur J Neurosci. 2012 Jul;36(2):2146-55
pubmed: 22805060
Hum Brain Mapp. 2000 Jul;10(3):120-31
pubmed: 10912591
Clin Neurophysiol. 2006 Jan;117(1):110-7
pubmed: 16316780
Mol Psychiatry. 2010 Aug;15(8):823-30
pubmed: 20065955
Neuroimage. 2008 Oct 1;42(4):1481-9
pubmed: 18634887
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11793-9
pubmed: 11050211
Biol Psychiatry. 2011 May 15;69(10):989-96
pubmed: 21216392
Psychophysiology. 2008 Sep;45(5):812-24
pubmed: 18665866
Schizophr Res. 2012 Oct;141(1):1-7
pubmed: 22910401
Biol Psychiatry. 2005 Nov 1;58(9):713-23
pubmed: 15993858
Neuroimage. 2003 Oct;20(2):995-1005
pubmed: 14568469
Schizophr Res. 2012 Dec;142(1-3):96-8
pubmed: 23062750
Suppl Clin Neurophysiol. 2013;62:163-80
pubmed: 24053039
PLoS Biol. 2009 Jun;7(6):e1000129
pubmed: 19529760
Brain Topogr. 2018 May;31(3):419-429
pubmed: 29218677
JAMA Psychiatry. 2016 Nov 01;73(11):1145-1153
pubmed: 27732692
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2643-7
pubmed: 6941317
Neuroimage. 2014 Sep;98:487-505
pubmed: 24990357
Schizophr Res. 2012 Apr;136(1-3):143-9
pubmed: 22285558
J Neurophysiol. 2008 May;99(5):2656-71
pubmed: 18287555
Hear Res. 2013 Feb;296:25-35
pubmed: 23174483
Neuroimage Clin. 2019;22:101732
pubmed: 30851675
Neuropsychopharmacology. 2017 Dec;42(13):2633-2639
pubmed: 28425497
Schizophr Res. 2018 Nov;201:278-286
pubmed: 29807805
Neuroimage. 2017 Mar 1;148:240-253
pubmed: 28110090
Eur Arch Otorhinolaryngol. 2016 Feb;273(2):349-54
pubmed: 25682179
Neuroimage. 2017 Feb 15;147:726-735
pubmed: 27902936
Neuroimage Clin. 2013 May 15;2:695-702
pubmed: 24179821
Hear Res. 1996 Nov 1;101(1-2):62-74
pubmed: 8951433
J Neurol Neurosurg Psychiatry. 1999 Mar;66(3):365-9
pubmed: 10084536
Scand Audiol Suppl. 1999;51:23-32
pubmed: 10803911
Hum Brain Mapp. 2021 Feb 15;42(3):780-796
pubmed: 33166050
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
Hear Res. 2003 Dec;186(1-2):57-68
pubmed: 14644459
Front Neurosci. 2014 Aug 28;8:258
pubmed: 25221467
Front Hum Neurosci. 2017 Jun 28;11:345
pubmed: 28701944
Nature. 2014 Jun 5;510(7503):143-7
pubmed: 24739966
Am J Psychiatry. 2003 Dec;160(12):2238-40
pubmed: 14638599
Schizophr Bull. 2019 Jun 18;45(4):859-870
pubmed: 30099543
Clin Neurophysiol. 1999 May;110(5):856-68
pubmed: 10400199
Brain Connect. 2017 Apr;7(3):152-171
pubmed: 28398812
J Neurosci Methods. 2008 Jun 30;171(2):331-9
pubmed: 18471892
Neuroimage Clin. 2016 Dec 19;13:395-404
pubmed: 28116232
Nat Neurosci. 2010 Aug;13(8):1011-9
pubmed: 20622871
Psychophysiology. 2018 Aug;55(8):e13074
pubmed: 29570815
Neuron. 2011 Jan 27;69(2):387-96
pubmed: 21262474
Schizophr Res. 2005 Oct 15;78(2-3):269-84
pubmed: 16002265
Neuroimage. 2011 Jan 1;54(1):495-504
pubmed: 20688174
Cereb Cortex. 2008 Feb;18(2):371-8
pubmed: 17557901
Biol Psychiatry. 2010 Feb 1;67(3):224-31
pubmed: 19765689
Neuroimage. 2019 May 1;191:303-314
pubmed: 30794868
Biol Psychiatry. 2008 Sep 1;64(5):369-75
pubmed: 18400208
Hear Res. 2002 Mar;165(1-2):68-84
pubmed: 12031517
J Acoust Soc Am. 2000 Aug;108(2):679-91
pubmed: 10955634
Hear Res. 2004 Aug;194(1-2):73-80
pubmed: 15276678
JAMA Psychiatry. 2015 Aug;72(8):813-21
pubmed: 25587799
Schizophr Res. 2012 Jun;138(1):1-7
pubmed: 22542616
Neuroimage. 2009 Oct 1;47(4):1711-9
pubmed: 19371786
Biol Psychiatry. 2010 Jul 1;68(1):41-50
pubmed: 20609836
Brain Res. 1999 Jan 30;817(1-2):45-58
pubmed: 9889315
Biol Psychiatry. 2006 Dec 1;60(11):1231-40
pubmed: 16893524
Cereb Cortex. 2016 Mar;26(3):1027-1035
pubmed: 25452567
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Brain. 2019 Oct 1;142(10):2938-2947
pubmed: 31504236
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:14-9
pubmed: 24075897
Clin Neurophysiol. 2004 Aug;115(8):1863-74
pubmed: 15261865
Dev Neurosci. 2016;38(1):1-14
pubmed: 26730806
Suppl Clin Neurophysiol. 2013;62:101-12
pubmed: 24053034
Schizophr Bull. 2018 Feb 15;44(2):378-387
pubmed: 29036430
Psychiatr Serv. 2007 Apr;58(4):529-35
pubmed: 17412856
Cereb Cortex. 2015 Jun;25(6):1509-18
pubmed: 24334917
Arch Gen Psychiatry. 2003 Sep;60(9):878-88
pubmed: 12963669
Neuroimage Clin. 2013 Nov 22;4:122-9
pubmed: 24371794
Schizophr Res. 2012 Aug;139(1-3):1-6
pubmed: 22647883
Clin Neurophysiol. 2010 Feb;121(2):200-7
pubmed: 20005163
BMC Neurosci. 2009 Jul 20;10:85
pubmed: 19619324
IEEE Trans Biomed Eng. 2008 Mar;55(3):1092-102
pubmed: 18334401