Crystal Structure and Biochemical Analysis of a Cytochrome P450 Steroid Hydroxylase (


Journal

Journal of microbiology and biotechnology
ISSN: 1738-8872
Titre abrégé: J Microbiol Biotechnol
Pays: Korea (South)
ID NLM: 9431852

Informations de publication

Date de publication:
28 Mar 2023
Historique:
received: 16 11 2022
revised: 05 12 2022
accepted: 06 12 2022
medline: 29 3 2023
pubmed: 20 1 2023
entrez: 19 1 2023
Statut: ppublish

Résumé

Cytochrome P450 (CYP) is a heme-containing enzyme that catalyzes hydroxylation reactions with various substrate molecules. Steroid hydroxylases are particularly useful for effectively introducing hydroxyl groups into a wide range of steroids in the pharmaceutical industry. This study reports a newly identified CYP steroid hydroxylase (

Identifiants

pubmed: 36655276
pii: jmb.2211.11031
doi: 10.4014/jmb.2211.11031
pmc: PMC10084758
doi:

Substances chimiques

Cytochrome P-450 Enzyme System 9035-51-2
Steroid Hydroxylases EC 1.14.-
Steroids 0
Progesterone 4G7DS2Q64Y

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

387-397

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Auteurs

Ki-Hwa Kim (KH)

Department of Life Science and Biochemical Engineering, Sunmoon University, Asan 31460, Republic of Korea.

Hackwon Do (H)

Research Unit of Cryogenic Novel Materials, Korea Polar Research Institute, Incheon 21990, Republic of Korea.
Department of Polar Sciences, University of Science and Technology, Incheon 21990, Republic of Korea.

Chang Woo Lee (CW)

Research Unit of Cryogenic Novel Materials, Korea Polar Research Institute, Incheon 21990, Republic of Korea.

Pradeep Subedi (P)

Department of Life Science and Biochemical Engineering, Sunmoon University, Asan 31460, Republic of Korea.

Mieyoung Choi (M)

Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Asan 31460, Republic of Korea.

Yewon Nam (Y)

Research Unit of Cryogenic Novel Materials, Korea Polar Research Institute, Incheon 21990, Republic of Korea.

Jun Hyuck Lee (JH)

Research Unit of Cryogenic Novel Materials, Korea Polar Research Institute, Incheon 21990, Republic of Korea.
Department of Polar Sciences, University of Science and Technology, Incheon 21990, Republic of Korea.

Tae-Jin Oh (TJ)

Department of Life Science and Biochemical Engineering, Sunmoon University, Asan 31460, Republic of Korea.
Department of Pharmaceutical Engineering and Biotechnology, Sunmoon University, Asan 31460, Republic of Korea.
Genome-based BioIT Convergence Institute, Asan 31460, Republic of Korea.

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Classifications MeSH