The Circadian Biology of Heart Failure.
biological clocks
chronotherapy
circadian clocks
circadian rhythm
heart failure
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
20 01 2023
20 01 2023
Historique:
pmc-release:
20
01
2024
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
24
1
2023
Statut:
ppublish
Résumé
Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly or entirely circadian. Cardiac contractility, metabolism, and electrophysiology, all have diurnal rhythms, as does the neurohumoral control of cardiac and kidney function. In this review, we discuss the evidence that circadian biology regulates cardiac function, how molecular clocks may relate to the pathogenesis of heart failure, and how chronotherapeutics might be applied in heart failure. Disrupting molecular clocks can lead to heart failure in animal models, and the myocardial response to injury seems to be conditioned by the time of day. Human studies are consistent with these findings, and they implicate the clock and circadian rhythms in the pathogenesis of heart failure. Certain circadian rhythms are maintained in patients with heart failure, a factor that can guide optimal timing of therapy. Pharmacologic and nonpharmacologic manipulation of circadian rhythms and molecular clocks show promise in the prevention and treatment of heart failure.
Identifiants
pubmed: 36656971
doi: 10.1161/CIRCRESAHA.122.321369
pmc: PMC9869465
mid: NIHMS1854743
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
223-237Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001878
Pays : United States
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