Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats.
Humans
Rats
Animals
Dopamine Plasma Membrane Transport Proteins
Synthetic Cathinone
Methamphetamine
/ pharmacology
Central Nervous System Agents
Serotonin Plasma Membrane Transport Proteins
Illicit Drugs
Norepinephrine Plasma Membrane Transport Proteins
Central Nervous System Stimulants
/ pharmacology
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
18
08
2022
accepted:
12
01
2023
medline:
19
5
2023
pubmed:
21
1
2023
entrez:
20
1
2023
Statut:
ppublish
Résumé
Synthetic cathinones are a class of new psychoactive substances that display psychomotor stimulant properties, and novel cathinone analogs continue to emerge in illicit drug markets worldwide. The aim of the present study was to characterize the pharmacology of 4-chloro ring-substituted cathinones that are appearing in illicit drug markets compared with the effects of 4-methylmethcathinone (mephedrone). Synaptosomes were prepared from rat caudate for dopamine transporter (DAT) assays or from whole brain minus caudate and cerebellum for norepinephrine transporter (NET) and serotonin transporter (SERT) assays. Findings from transporter uptake inhibition and release assays showed that mephedrone and 4-chloromethcathinone (4-CMC) function as substrates at DAT, NET, and SERT, with similar potency at all three transporters. In contrast, 4-chloro-
Identifiants
pubmed: 36669877
pii: jpet.122.001478
doi: 10.1124/jpet.122.001478
pmc: PMC10201577
doi:
Substances chimiques
mephedrone
8BA8T27317
clephedrone
PTAYYYZMMT
Dopamine Plasma Membrane Transport Proteins
0
Synthetic Cathinone
0
Methamphetamine
44RAL3456C
Central Nervous System Agents
0
Serotonin Plasma Membrane Transport Proteins
0
Illicit Drugs
0
Norepinephrine Plasma Membrane Transport Proteins
0
Central Nervous System Stimulants
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-170Subventions
Organisme : Intramural NIH HHS
ID : Z01 DA000523
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DA000532
Pays : United States
Informations de copyright
U.S. Government work not protected by U.S. copyright.
Déclaration de conflit d'intérêts
No author has an actual or perceived conflict of interest with the contents of this article.
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