Experimental and Bioinformatic Insights into the Effects of Epileptogenic Variants on the Function and Trafficking of the GABA Transporter GAT-1.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
04 Jan 2023
Historique:
received: 29 11 2022
revised: 27 12 2022
accepted: 31 12 2022
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 25 1 2023
Statut: epublish

Résumé

In this article, we identified a novel epileptogenic variant (G307R) of the gene

Identifiants

pubmed: 36674476
pii: ijms24020955
doi: 10.3390/ijms24020955
pmc: PMC9862756
pii:
doi:

Substances chimiques

GABA Plasma Membrane Transport Proteins 0
Lipid Bilayers 0
SLC6A1 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Spanish Ministry Science and Innovation
ID : RTI2018-098712-B-I00
Organisme : Spanish Ministry Science and Innovation
ID : PID2019-109041GB-C22/10.13039/501100011033
Organisme : Ministry of Health, Carlos III/FEDER
ID : PI20/00389
Organisme : Spanish Ministry of Universities
ID : FPU18/02152
Organisme : Autonomous University of Madrid
ID : CA1/RSUE/2021-00753

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Auteurs

Dolores Piniella (D)

Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
IdiPAZ, Institute of Health Carlos III (ISCIII), 28046 Madrid, Spain.

Ania Canseco (A)

Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Silvia Vidal (S)

Sant Joan de Déu Research Foundation, 08950 Barcelona, Spain.
IPER, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, 08950 Barcelona, Spain.

Clara Xiol (C)

Sant Joan de Déu Research Foundation, 08950 Barcelona, Spain.
IPER, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, 08950 Barcelona, Spain.

Aránzazu Díaz de Bustamante (A)

Genetics Unit, Hospital Universitario de Móstoles, 28935 Madrid, Spain.

Itxaso Martí-Carrera (I)

Pediatric Neurology, Hospital Universitario Donostia, Biodonostia, Universidad del País Vasco UPV-EHU, 20014 San Sebastián, Spain.

Judith Armstrong (J)

IPER, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, 08950 Barcelona, Spain.
Molecular and Genetics Medicine Section, Hospital Sant Joan de Déu, 08950 Barcelona, Spain.
CIBER-ER (Biomedical Network Research Center for Rare Diseases), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.

Ugo Bastolla (U)

Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Francisco Zafra (F)

Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
IdiPAZ, Institute of Health Carlos III (ISCIII), 28046 Madrid, Spain.

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Classifications MeSH