A Mixture of Dietary Plant Sterols at Nutritional Relevant Serum Concentration Inhibits Extrinsic Pathway of Eryptosis Induced by Cigarette Smoke Extract.
DISC
caspases
cigarette smoke
eryptosis
p38 MAPK
plant sterols
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jan 2023
09 Jan 2023
Historique:
received:
16
12
2022
revised:
05
01
2023
accepted:
06
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Cell death program of red blood cells (RBCs), called eryptosis, is characterized by activation of caspases and scrambling of membrane phospholipids with externalization of phosphatidylserine (PS). Excessive eryptosis confers a procoagulant phenotype and is implicated in impairment of microcirculation and increased prothrombotic risk. It has recently been reported that cigarette smokers have high levels of circulating eryptotic erythrocytes, and a possible contribution of eryptosis to the vaso-occlusive complications associated to cigarette smoke has been postulated. In this study, we demonstrate how a mixture of plant sterols (MPtS) consisting of β-sitosterol, campesterol and stigmasterol, at serum concentration reached after ingestion of a drink enriched with plant sterols, inhibits eryptosis induced by cigarette smoke extract (CSE). Isolated RBCs were exposed for 4 h to CSE (10-20%
Identifiants
pubmed: 36674779
pii: ijms24021264
doi: 10.3390/ijms24021264
pmc: PMC9861561
pii:
doi:
Substances chimiques
Phytosterols
0
Calcium
SY7Q814VUP
Phosphatidylserines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MCIN/AEI/10.13039/501100011033 (Ministry of Science and Innovation (Spain)
ID : PID2019-104167RB-I00
Organisme : EUROPEAN UNION 2014-2020 PON RICERCA E INNOVAZIONE GRANT FROM THE ITALIAN MINISTRY OF EDUCATION, UNIVERSITY AND RESEARCH, ENTITLED "PROGEMA-PROCESSI GREEN PER L'ESTRAZIONE DI PRINCIPI ATTIVI E LA DEPURA-ZIONE DI MATRICI DI SCARTO E NON"
ID : (ARS01_00432/)
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