Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 M

Antiviral Agents / pharmacology Diazomethane / chemistry Molecular Docking Simulation Protease Inhibitors / chemistry SARS-CoV-2 / drug effects
COVID-19 SARS-CoV-2 SARS-CoV-2 Mpro coronavirus cysteine proteases diazirines enzymatic inhibitors

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
04 Jan 2023
Historique:
received: 28 11 2022
revised: 26 12 2022
accepted: 29 12 2022
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 25 1 2023
Statut: epublish

Résumé

SARS-CoV-2 M

Identifiants

DOI: 10.3390/molecules28020514 PMID: 36677572 PMC: PMC9864213
pubmed: 36677572
pii: molecules28020514
doi: 10.3390/molecules28020514
pmc: PMC9864213
pii:
doi:

Substances chimiques

Antiviral Agents 0
Diazomethane 60A625P70P
Protease Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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pubmed: 33573283

Auteurs

Andrea Citarella (A)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0001-5881-7142

Davide Moi (D)

Dipartimento di Scienze Chimiche e Geologiche, University of Cagliari, Cittadella Universitaria-S.S. 554 bivio per Sestu, 09042 Monserrato, Italy.
ORCID: 0000-0002-2470-9351

Martina Pedrini (M)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0003-4332-7241

Helena Pérez-Peña (H)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0001-7938-4307

Stefano Pieraccini (S)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0002-7672-0720

Claudio Stagno (C)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

Nicola Micale (N)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
ORCID: 0000-0002-9294-6033

Tanja Schirmeister (T)

Department of Medicinal Chemistry, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.

Giulia Sibille (G)

Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Torino, Italy.
ORCID: 0000-0002-2869-357X

Giorgio Gribaudo (G)

Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Torino, Italy.
ORCID: 0000-0002-1583-9146

Alessandra Silvani (A)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0002-0397-2636

Daniele Passarella (D)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0001-6180-9581

Clelia Giannini (C)

Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
ORCID: 0000-0003-3376-8350

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Discovery of a Novel Trifluoromethyl Diazirine...
questionsmedicales.fr › Composés chimiques organiques › Composés azoïques › Composés diazonium › Diazo-méthane › Discovery of a Novel Trifluoromethyl Diazirine...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Discovery of a Novel Trifluoromethyl Diazirine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Discovery of a Novel Trifluoromethyl Diazirine...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Discovery of a Novel Trifluoromethyl Diazirine...