Soluble Guanylyl Cyclase Activators-Promising Therapeutic Option in the Pharmacotherapy of Heart Failure and Pulmonary Hypertension.
chronic heart failure (CHF)
guanylate cyclase (GC)
pulmonary arterial hypertension (PAH)
riociguat
vericiguat
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Jan 2023
15 Jan 2023
Historique:
received:
05
11
2022
revised:
26
12
2022
accepted:
13
01
2023
entrez:
21
1
2023
pubmed:
22
1
2023
medline:
25
1
2023
Statut:
epublish
Résumé
Endogenous nitric oxide (NO)-dependent vascular relaxation plays a leading role in the homeostasis of the cardiovascular, pulmonary, and vascular systems and organs, such as the kidneys, brain, and liver. The mechanism of the intracellular action of NO in blood vessels involves the stimulation of the activity of the soluble cytosolic form of guanylyl cyclase (soluble guanylyl cyclase, sGC), increasing the level of cyclic 3'-5'-guanosine monophosphate (cGMP) in smooth muscle and subsequent vasodilation. In recent years, a new group of drugs, soluble guanylyl cyclase stimulators, has found its way into clinical practice. Based on the CHEST-1 and PATENT-1 trials, riociguat was introduced into clinical practice for treating chronic thromboembolic pulmonary hypertension (CTEPH). In January 2021, the FDA approved the use of another drug, vericiguat, for the treatment of heart failure.
Identifiants
pubmed: 36677920
pii: molecules28020861
doi: 10.3390/molecules28020861
pmc: PMC9862932
pii:
doi:
Substances chimiques
Soluble Guanylyl Cyclase
EC 4.6.1.2
Guanylate Cyclase
EC 4.6.1.2
Cyclic GMP
H2D2X058MU
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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