Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance.

Rats Mice Animals Rats, Inbred WKY Glucose Intolerance / drug therapy Insulin Resistance Hypoglycemic Agents / pharmacology Liraglutide / pharmacology Prolactin-Releasing Hormone / pharmacology Prediabetic State / drug therapy Obesity / drug therapy Lipids Diet, High-Fat / adverse effects
Wistar Kyoto rats astrocytosis diet-induced obesity glucose intolerance lipid metabolism lipidomics liraglutide metabolomics prolactin-releasing peptide

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
05 Jan 2023
Historique:
received: 25 11 2022
revised: 28 12 2022
accepted: 30 12 2022
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 25 1 2023
Statut: epublish

Résumé

Prolactin-releasing peptide (PrRP) is an anorexigenic neuropeptide that has potential for the treatment of obesity and its complications. Recently, we designed a palmitoylated PrRP31 analog (palm

Identifiants

DOI: 10.3390/nu15020280 PMID: 36678151 PMC: PMC9864151
pubmed: 36678151
pii: nu15020280
doi: 10.3390/nu15020280
pmc: PMC9864151
pii:
doi:

Substances chimiques

Hypoglycemic Agents 0
Liraglutide 839I73S42A
Prolactin-Releasing Hormone 0
Lipids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Czech Science Foundation
ID : 20-00546S
Organisme : European Union - Next Generation EU
ID : LX22NP05104

Références

Analyst. 2020 Jul 7;145(13):4595-4605
pubmed: 32436545
Obesity (Silver Spring). 2011 Jul;19(7):1342-9
pubmed: 21415845
Expert Rev Gastroenterol Hepatol. 2009 Aug;3(4):445-51
pubmed: 19673631
Neuropharmacology. 2019 Jan;144:377-387
pubmed: 30428311
Int J Exp Pathol. 2020 Oct;101(5):152-161
pubmed: 32783310
Front Nutr. 2022 Jan 07;8:783302
pubmed: 35071294
Biofactors. 2016 Nov 12;42(6):600-611
pubmed: 27213962
J Physiol Pharmacol. 2016 Feb;67(1):121-8
pubmed: 27010901
Anal Chem. 2006 Jul 1;78(13):4281-90
pubmed: 16808434
J Physiol. 2022 Sep;600(18):4137-4151
pubmed: 35974660
Int J Obes (Lond). 2015 Jun;39(6):986-93
pubmed: 25771926
Cell Metab. 2016 Oct 11;24(4):555-565
pubmed: 27693377
Peptides. 2016 Jan;75:109-17
pubmed: 26643957
Acta Pharmacol Sin. 2012 Feb;33(2):194-200
pubmed: 22301859
Int J Obes (Lond). 2018 Aug;42(8):1445-1457
pubmed: 29789721
J Mol Endocrinol. 2018 Feb;60(2):85-94
pubmed: 29233862
Am J Hypertens. 2001 Jan;14(1):51-3
pubmed: 11206679
Metabolism. 2015 Nov;64(11):1376-85
pubmed: 26342499
J Hepatol. 2021 Sep;75(3):524-535
pubmed: 33887358
Sci Rep. 2016 Jun 10;6:27688
pubmed: 27282822
Front Endocrinol (Lausanne). 2019 Apr 12;10:155
pubmed: 31031702
Peptides. 2020 Sep;131:170342
pubmed: 32522585
Endocrinology. 2014 Sep;155(9):3288-301
pubmed: 24949659
IUBMB Life. 2015 Jul;67(7):506-13
pubmed: 26177573
Bioanalysis. 2018 Jan;10(2):71-81
pubmed: 29243489
Gene. 2021 Mar 30;774:145427
pubmed: 33450349
Anal Bioanal Chem. 2016 Jan;408(2):567-78
pubmed: 26577083
Drug Des Devel Ther. 2015 Mar 30;9:1867-75
pubmed: 25848222
Bioanalysis. 2017 Sep;9(17):1319-1328
pubmed: 28901165
J Biosci. 2007 Mar;32(2):405-13
pubmed: 17435330
J Cardiovasc Nurs. 2002 Jan;16(2):1-16
pubmed: 11800064
Metabolites. 2020 Apr 24;10(4):
pubmed: 32344559
Nat Metab. 2021 Mar;3(3):309-317
pubmed: 33758421
Arch Toxicol. 1991;65(7):548-55
pubmed: 1685880
Diabetes. 2005 Mar;54(3):648-56
pubmed: 15734839
Curr Obes Rep. 2015 Dec;4(4):451-9
pubmed: 26346394
Horm Metab Res. 2022 Apr;54(4):203-211
pubmed: 35413740
Lancet. 2016 May 7;387(10031):1947-56
pubmed: 26868660
Biochim Biophys Acta. 2002 May 21;1587(1):83-91
pubmed: 12009428
J Alzheimers Dis. 2015;45(3):823-35
pubmed: 25624414
Adv Exp Med Biol. 2017;960:1-17
pubmed: 28585193
Trends Endocrinol Metab. 2013 Feb;24(2):85-91
pubmed: 23332584
Nat Rev Endocrinol. 2019 May;15(5):288-298
pubmed: 30814686
J Proteome Res. 2019 Apr 5;18(4):1735-1750
pubmed: 30810318
J Proteome Res. 2012 Apr 6;11(4):2544-50
pubmed: 22401608
BMB Rep. 2012 Jul;45(7):419-24
pubmed: 22831978
Intern Emerg Med. 2022 Nov 10;:
pubmed: 36357606
Chimia (Aarau). 2014;68(3):146-9
pubmed: 24801845
J Proteome Res. 2015 May 1;14(5):2237-54
pubmed: 25784267
Front Pharmacol. 2021 Nov 18;12:779962
pubmed: 34867411
Nutr Diabetes. 2018 Jan 16;8(1):5
pubmed: 29339795
Diabetes Res Clin Pract. 2012 Aug;97(2):258-66
pubmed: 22446097
Curr Protoc Bioinformatics. 2019 Dec;68(1):e86
pubmed: 31756036
J Endocrinol. 2016 May;229(2):85-96
pubmed: 26906745
PLoS One. 2017 Aug 18;12(8):e0183449
pubmed: 28820912
J Mol Endocrinol. 2020 Feb;64(2):77-90
pubmed: 31855558

Auteurs

Lucia Mráziková (L)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.

Silvie Hojná (S)

Institute of Physiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.

Petra Vaculová (P)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.

Štěpán Strnad (Š)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.
ORCID: 0000-0002-0769-2420

Vladimír Vrkoslav (V)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.
ORCID: 0000-0002-5126-8360

Helena Pelantová (H)

Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
ORCID: 0000-0002-2523-7413

Marek Kuzma (M)

Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.

Blanka Železná (B)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.

Jaroslav Kuneš (J)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.
Institute of Physiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.

Lenka Maletínská (L)

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.

Articles similaires

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Eucaryotes › Animaux › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée WKY › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Intolérance au glucose › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Liraglutide › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormone de libération de la prolactine › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Maladies endocriniennes › Diabète › État prédiabétique › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Lipides › Lipidized PrRP Analog Exhibits Strong...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Lipidized PrRP Analog Exhibits Strong...