Corticosteroid-binding globulin (CBG): spatiotemporal distribution of cortisol in sepsis.

Humans Hydrocortisone / metabolism Shock, Septic / metabolism Transcortin / metabolism Sepsis Fever
CBG corticosteroid-binding globulin cortisol sepsis transcortin

Journal

Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516

Informations de publication

Date de publication:
03 2023
Historique:
received: 26 09 2022
accepted: 02 01 2023
pubmed: 22 1 2023
medline: 18 2 2023
entrez: 21 1 2023
Statut: ppublish

Résumé

Corticosteroid-binding globulin (CBG) is a 50-60 kDa circulating glycoprotein with high affinity for cortisol. CBG is adapted for sepsis; its cortisol binding is reduced reversibly by pyrexia and acidaemia, and reduced irreversibly by neutrophil elastase (NE) cleavage, converting high cortisol-binding affinity CBG to a low affinity form. These characteristics allow for the targeted delivery of immunomodulatory cortisol to tissues at the time and body site where cortisol is required in sepsis and septic shock. In addition, high titer inflammatory cytokines in sepsis suppress CBG hepatic synthesis, increasing the serum free cortisol fraction. Recent clinical studies have highlighted the importance of CBG in septic shock, with CBG deficiency independently associated with mortality.

Identifiants

DOI: 10.1016/j.tem.2023.01.002 PMID: 36681594
pubmed: 36681594
pii: S1043-2760(23)00013-9
doi: 10.1016/j.tem.2023.01.002
pii:
doi:

Substances chimiques

Hydrocortisone WI4X0X7BPJ
Transcortin 9010-38-2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

181-190

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests No interests are declared.

Auteurs

Jessica H Lee (JH)

Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

Emily J Meyer (EJ)

Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Department of Endocrine and Diabetes, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.

Marne A Nenke (MA)

Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Department of Endocrine and Diabetes, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.

Henrik Falhammar (H)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden. Electronic address: henrik.falhammar@ki.se.

David J Torpy (DJ)

Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Corticosteroid-binding globulin (CBG):...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › Corticosteroid-binding globulin (CBG):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Choc septique › Corticosteroid-binding globulin (CBG):...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Transcortine › Corticosteroid-binding globulin (CBG):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Corticosteroid-binding globulin (CBG):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Troubles de la température corporelle › Fièvre › Corticosteroid-binding globulin (CBG):...